| Gene Symbol |
PCM1
|
| Entrez Gene |
5108
|
| Alt Symbol |
PTC4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
pericentriolar material 1
|
| Other Description |
PCM-1|hPCM-1|pericentriolar material 1 protein|pericentriolar material 1, PCM1
|
| Swissprots |
Q9BWC1 Q6P1K7 Q8NB85 Q58F13 Q9H4A2 Q15154
|
| Accessions |
EAW63796 EAW63797 EAW63798 Q15154 AA931266 AF068293 AAF65182 AI810388 AI924817 AJ297349 CAC14882 AK091406 BAC03656 AK295856 BAG58662 AK301727 BAG63193 AK302378 BAG63697 AK307583 AL705025 AL712077 AW080255 AW237120 AW501568 AX785390 CAE11958 BC000453 AAH00453 BC027477 AAH27477 BC065022 AAH65022 BC098391 BC133052 AAI33053 BC140946 AAI40947 BF994051 BG898673 BI966701 BQ879089 BU166050 CB157569 CD704264 L27841 AAA60120 XM_005273521 XP_005273578 XM_006716336 XP_006716399 XM_006716340 XP_006716403 XM_006716343 XP_006716406 XM_006716344 XP_006716407 XM_006716346 XP_006716409 XM_006716347 XP_006716410 XM_006716348 XP_006716411 XM_006716349 XP_006716412 XM_011544528 XP_011542830 XM_011544529 XP_011542831 XM_011544530 XP_011542832 XM_011544531 XP_011542833 XM_011544532 XP_011542834 XM_011544533 XP_011542835 XM_011544534 XP_011542836 XM_011544535 XP_011542837 XM_011544536 XP_011542838 XM_011544537 XP_011542839 XM_011544538 XP_011542840 XM_011544539 XP_011542841 XM_011544540 XP_011542842 XM_011544541 XP_011542843 XM_011544542 XP_011542844 XM_011544543 XP_011542845 XR_949413 NM_006197 NP_006188
|
| Function |
Required for centrosome assembly and function. Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2. Required to anchor microtubules to the centrosome. Involved in the biogenesis of cilia. {ECO:0000269|PubMed:12403812, ECO:0000269|PubMed:15659651, ECO:0000269|PubMed:16943179, ECO:0000269|PubMed:20551181, ECO:0000269|PubMed:24121310}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic granule. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton, cilium basal body. Note=Recruitement to the centrosome requires microtubules and dynein. The majority of the protein dissociates from the centrosome during metaphase and subsequently localizes to the cleavage site in telophase. Displaced from centriolar satellites and centrosome in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock, in a process that requires p38 MAP kinase signaling.
|
| Tissue Specificity |
Expressed in blood, bone marrow, breast, lymph node, ovary and thyroid. {ECO:0000269|PubMed:10980597, ECO:0000269|PubMed:15184884, ECO:0000269|PubMed:16270321, ECO:0000269|PubMed:16424865}.
|