ATP1A2
| Gene Symbol | ATP1A2 |
|---|---|
| Entrez Gene | 477 |
| Alt Symbol | FHM2, MHP2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ATPase, Na+/K+ transporting, alpha 2 polypeptide |
| Other Description | Na(+)/K(+) ATPase alpha-2 subunit|Na+/K+ ATPase, alpha-A(+) catalytic polypeptide|Na+/K+ ATPase, alpha-B polypeptide|sodium pump subunit alpha-2|sodium-potassium ATPase catalytic subunit alpha-2|sodium/potassium-transporting ATPase alpha-2 chain|sodium/potassium-transporting ATPase subunit alpha-2 |
| Swissprots | Q9UQ25 Q86UZ5 Q5JW74 P50993 Q07059 D3DVE4 |
| Accessions | AAA35575 AAA51797 EAW52739 EAW52740 EAW52741 EAW52742 P50993 AB018321 BAA34498 AK091617 BAG52393 AK124581 BAG54055 AK126573 BAG54347 AK295048 BAG58098 AK295729 BAG58570 AK299460 BAG61427 AK308773 AK314296 BAG36951 AL831991 AL831997 AY946014 AAX55909 BC013680 BC047533 BC052271 AAH52271 DA221602 EB386326 M16795 AAA51799 Y07494 CAA68793 NM_000702 NP_000693 |
| Function | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients. |
| Subcellular Location | Membrane {ECO:0000269|PubMed:7711835}; Multi-pass membrane protein {ECO:0000269|PubMed:7711835}. Cell membrane {ECO:0000269|PubMed:7711835}; Multi-pass membrane protein {ECO:0000269|PubMed:7711835}. |
| Top Pathways | Salivary secretion, Cardiac muscle contraction, cAMP signaling pathway, Aldosterone-regulated sodium reabsorption, Thyroid hormone synthesis |
Na + /K + -ATPase α2 siRNA (h) - sc-42660 from Santa Cruz Biotechnology
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Na + /K + -ATPase α2 shRNA Plasmid (h) - sc-42660-SH from Santa Cruz Biotechnology
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Na + /K + -ATPase α2 shRNA (h) Lentiviral Particles - sc-42660-V from Santa Cruz Biotechnology
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Na + /K + -ATPase α2 CRISPR/Cas9 KO Plasmid (h) - sc-401939 from Santa Cruz Biotechnology
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Na + /K + -ATPase α2 HDR Plasmid (h) - sc-401939-HDR from Santa Cruz Biotechnology
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Na + /K + -ATPase α2 Double Nickase Plasmid (h) - sc-401939-NIC from Santa Cruz Biotechnology
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Na + /K + -ATPase α2 Double Nickase Plasmid (h2) - sc-401939-NIC-2 from Santa Cruz Biotechnology
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Na + /K + -ATPase α2 CRISPR Activation Plasmid (h) - sc-401939-ACT from Santa Cruz Biotechnology
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Na + /K + -ATPase α2 CRISPR Activation Plasmid (h2) - sc-401939-ACT-2 from Santa Cruz Biotechnology
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Na + /K + -ATPase α2 Lentiviral Activation Particles (h) - sc-401939-LAC from Santa Cruz Biotechnology
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Na + /K + -ATPase α2 Lentiviral Activation Particles (h2) - sc-401939-LAC-2 from Santa Cruz Biotechnology
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Sodium Potassium ATPase Alpha 2 RNAi - H00000477-R02 from Novus Biologicals
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MISSION® esiRNA - EHU134991 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1787 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1787 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11176 from Sigma-Aldrich
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ATP1A2 siRNA (Human) - CRH0333 from Cohesion Biosciences
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ATP1A2 - MBS8233280 from MyBioSource
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Na+/K+-ATPase α2 CRISPR/Cas9 KO Plasmid (h2) - sc-401939-KO-2 from Santa Cruz Biotechnology
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Na+/K+-ATPase α2 HDR Plasmid (h2) - sc-401939-HDR-2 from Santa Cruz Biotechnology
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Human ATP1A2 siRNA - orb260835 from Biorbyt
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ATP1A2 shRNA Plasmid (Human) - CHH0333 from Cohesion Biosciences
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ATP1A2 miRNA 3'UTR clone - MiUTR4H-TG00601 from Creative biogene
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