| Gene Symbol |
HP1BP3
|
| Entrez Gene |
50809
|
| Alt Symbol |
HP1-BP74, HP1BP74
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
heterochromatin protein 1, binding protein 3
|
| Other Description |
HP1-BP74|heterochromatin protein 1-binding protein 3
|
| Swissprots |
Q5SWC6 Q5SSJ5 Q9UHY0 Q6PIM9 B3KMZ8 Q5SSJ6 A8K5D7 Q05BI0 Q8NDF0 A6NI71 B4E210
|
| Accessions |
CAE91644 CCQ43536 EAW94950 EAW94951 EAW94952 EAW94953 Q5SSJ5 AF113534 AAF14871 AK023129 BAG51160 AK025754 AK291252 BAF83941 AK303456 BAG64500 AK304065 BAG64972 AL833978 CAD38822 BC032139 AAH32139 BC045660 AAH45660 BC046170 BC053327 BE247224 BM312215 CK000759 EU832526 ACE87698 XM_005245875 XP_005245932 XM_005245876 XP_005245933 XM_005245877 XP_005245934 XM_005245878 XP_005245935 XM_005245879 XP_005245936 XM_011541532 XP_011539834 XM_011541533 XP_011539835 XM_011541534 XP_011539836 XM_011541535 XP_011539837 NM_016287 NP_057371
|
| Function |
Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self- renewal(PubMed:25100860). {ECO:0000269|PubMed:24830416, ECO:0000269|PubMed:25100860}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:24830416}. Chromosome {ECO:0000269|PubMed:20042602, ECO:0000269|PubMed:24830416}. Note=localized in nuclei but not in nucleoli in interphase. Colocalized with chromosomes in mitosis, with a gradually increased during G1 progression and a maximum level during late G1 phase (G1/S). {ECO:0000269|PubMed:24830416}.
|