Gene Symbol | SPG11 |
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Entrez Gene | 80208 |
Alt Symbol | KIAA1840 |
Species | Human |
Gene Type | protein-coding |
Description | spastic paraplegia 11 (autosomal recessive) |
Other Description | colorectal carcinoma-associated protein|spastic paraplegia 11 protein|spatacsin |
Swissprots | Q8N270 B9EK60 Q58G86 F5H3N6 Q8TBU9 A8KAX9 Q9H734 Q96JI7 Q4VC11 Q6NW01 Q69YG6 |
Accessions | EAW77272 EAW77273 Q96JI7 AB058743 BAB47469 AB470308 BAH58758 AB470309 BAH58759 AB470310 BAH58760 AK025092 BAB15065 AK057869 AK091176 BAC03600 AK094331 BAC04333 AK225186 AL834168 CAH10686 AY954502 AAX54692 BC024161 AAH24161 BC047416 BC067798 AAH67798 BC094704 AAH94704 BC150640 AAI50641 BC153879 AAI53880 DA926289 XM_005254695 XP_005254752 XM_006720700 XP_006720763 XM_006720701 XP_006720764 XM_011522093 XP_011520395 XR_931917 NM_001160227 NP_001153699 NM_025137 NP_079413 |
Subcellular Location | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm, cytosol {ECO:0000269|PubMed:17322883}. Nucleus {ECO:0000269|PubMed:17322883}. Note=Mainly cytoplasmic. |
Tissue Specificity | Expressed in all structures of brain, with a high expression in cerebellum. {ECO:0000269|PubMed:17322883}. |
Spatacsin CRISPR/Cas9 KO Plasmid (h) - sc-413361 from Santa Cruz Biotechnology
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Spatacsin HDR Plasmid (h) - sc-413361-HDR from Santa Cruz Biotechnology
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Spatacsin Double Nickase Plasmid (h) - sc-413361-NIC from Santa Cruz Biotechnology
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Spatacsin Double Nickase Plasmid (h2) - sc-413361-NIC-2 from Santa Cruz Biotechnology
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Spatacsin CRISPR Activation Plasmid (h) - sc-413361-ACT from Santa Cruz Biotechnology
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Spatacsin CRISPR Activation Plasmid (h2) - sc-413361-ACT-2 from Santa Cruz Biotechnology
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Spatacsin Lentiviral Activation Particles (h) - sc-413361-LAC from Santa Cruz Biotechnology
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Spatacsin Lentiviral Activation Particles (h2) - sc-413361-LAC-2 from Santa Cruz Biotechnology
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Spatacsin siRNA (h) - sc-90244 from Santa Cruz Biotechnology
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Spatacsin shRNA Plasmid (h) - sc-90244-SH from Santa Cruz Biotechnology
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Spatacsin shRNA (h) Lentiviral Particles - sc-90244-V from Santa Cruz Biotechnology
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SPG11 RNAi - H00080208-R01 from Novus Biologicals
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MISSION® esiRNA - EHU136071 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20461 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20461 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12127 from Sigma-Aldrich
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SPG11 siRNA (Human) - CRJ2802 from Cohesion Biosciences
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SPG11 - MBS8236080 from MyBioSource
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shRNA set against Human SPG11 (NM_025137.3) - SHH416552 from Creative biogene
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Human SPG11 siRNA - orb273303 from Biorbyt
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SPG11 shRNA Plasmid (Human) - CHJ2802 from Cohesion Biosciences
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SPG11 miRNA 3'UTR clone - MiUTR1H-05295 from Creative biogene
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SPG11 miRNA 3'UTR clone - MiUTR3H-11502 from Creative biogene
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