| Gene Symbol |
RTN4
|
| Entrez Gene |
57142
|
| Alt Symbol |
ASY, NI220/250, NOGO, NOGO-A, NOGOC, NSP, NSP-CL, Nbla00271, Nbla10545, Nogo-B, Nogo-C, RTN-X, RTN4-A, RTN4-B1, RTN4-B2, RTN4-C
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
reticulon 4
|
| Other Description |
Human NogoA|My043 protein|foocen|neurite growth inhibitor 220|neurite outgrowth inhibitor|neuroendocrine-specific protein C homolog|reticulon 5|reticulon-4
|
| Swissprots |
Q9Y293 Q9H3I3 Q8IUA4 Q9Y5U6 Q7L7Q8 O94962 Q9BXG5 Q9H212 Q9NQC3 Q7L7Q6 Q7L7Q5 Q9UQ42 Q9Y2Y7 Q96B16
|
| Accessions |
AAM64240 AAM64241 AAM64242 AAM64243 AAM64244 AAX93116 AAY24029 AAY24239 CAH03193 CAI79370 CAZ39560 CBL54390 CBX89232 EAX00115 EAX00116 EAX00117 EAX00118 EAX00119 EAX00120 EAX00121 EAX00122 EAX00123 EAX00124 EAX00125 EAX00126 EAX00127 EAX00128 EAX00129 EAX00130 EAX00131 EAX00132 Q9NQC3 AB015639 BAA83712 AB020693 BAA74909 AB040462 BAB18927 AB040463 BAB18928 AB073351 BAE45714 AB073359 BAE45717 AF063601 AAG43160 AF077050 AAD27783 AF087901 AAG12205 AF125103 AAD39920 AF132047 AAD31021 AF132048 AAD31022 AF148537 AAG12176 AF148538 AAG12177 AF177332 AAG17976 AF320999 AAG40878 AF333336 AAK20831 AI671568 AJ251383 CAB99248 AJ251384 CAB99249 AJ251385 CAB99250 AK075039 AK090714 AK093785 AK098385 AK129806 AK130812 AK172726 AK302741 BAG63956 AM392753 CAL37631 AM393104 CAL37982 AM393122 CAL38000 AM393280 CAL38158 AM393537 CAL38414 AM393557 CAL38434 AY102276 AAM64245 AY102277 AAM64246 AY102278 AAM64247 AY102279 AAM64248 AY123245 AAM64249 AY123246 AAM64250 AY123247 AAM64251 AY123248 AAM64252 AY123249 AAM64253 AY123250 AAM64254 BC001035 AAH01035 BC007109 AAH07109 BC010737 AAH10737 BC012619 AAH12619 BC014366 AAH14366 BC016165 AAH16165 BC026788 AAH26788 BC068991 AAH68991 BC071848 AAH71848 BC139928 AAI39929 BC150182 AAI50183 BC152425 AAI52426 BC152555 AAI52556 DQ778739 ABG76010 XM_005264434 XP_005264491 XM_011532991 XP_011531293 XM_011532992 XP_011531294 NM_007008 NP_008939 NM_020532 NP_065393 NM_153828 NP_722550 NM_207520 NP_997403 NM_207521 NP_997404
|
| Function |
Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing. {ECO:0000250, ECO:0000269|PubMed:10667797, ECO:0000269|PubMed:11201742, ECO:0000269|PubMed:16965550}.
|
| Subcellular Location |
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Anchored to the membrane of the endoplasmic reticulum through 2 putative transmembrane domains.
|
| Tissue Specificity |
Isoform 1 is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform 2 is widely expressed except for the liver. Isoform 3 is expressed in brain, skeletal muscle and adipocytes. Isoform 4 is testis- specific.
|