| Gene Symbol |
AOX1
|
| Entrez Gene |
100008601
|
| Alt Symbol |
-
|
| Species |
Rabbit
|
| Gene Type |
protein-coding
|
| Description |
aldehyde oxidase 1
|
| Other Description |
azaheterocycle hydroxylase 1|retinal oxidase|retinoic acid synthase
|
| Swissprots |
Q9XTA9 P80456
|
| Accessions |
CAW36622 CAW38956 CAW41137 CAW47153 CAW63573 CAW71803 CAW80295 CAW82787 CAW86103 CBC02575 CBC04828 CBC06788 CBC12863 CBC45693 CBC62112 CBC79048 CBC83993 CBC88943 P80456 AB009345 BAA81726 NM_001081990 NP_001075459
|
| Function |
Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide and N- methylphthalazinium, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also may catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis. Cannot use hypoxanthine and all-trans- retinol as substrate. {ECO:0000269|PubMed:10190983, ECO:0000269|PubMed:7556219, ECO:0000269|PubMed:8305467, ECO:0000269|PubMed:
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:8305467}.
|
| Tissue Specificity |
Very high expression in liver and lung. High expression in kidney, pancreas, brain stem and spinal cord. Moderate expression in heart, testis, eye, cerebral cortex and cerebellum. Low expression in stomach and muscle. {ECO:0000269|PubMed:10190983, ECO:0000269|PubMed:8305467}.
|
| Top Pathways |
Tyrosine metabolism, Tryptophan metabolism, Vitamin B6 metabolism, Nicotinate and nicotinamide metabolism, Retinol metabolism
|