| Gene Symbol |
MICB
|
| Entrez Gene |
4277
|
| Alt Symbol |
PERB11.2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
MHC class I polypeptide-related sequence B
|
| Other Description |
MHC class I chain-related protein B|MHC class I mic-B antigen|MHC class I-like molecule PERB11.2-IMX|stress inducible class I homolog
|
| Swissprots |
Q5GR37 A2AC57 Q9MY20 Q29980 Q9UBH4 Q5GR48 O19801 A6NP85 O78103 Q9UEJ0 O78102 O19800 Q9MY19 Q5SSK1 Q5GR41 P79541 O14500 Q7JK51 O78104 Q5GR44 O19798 Q5RIY6 Q5GR46 Q5ST25 O19803 Q7YQ89 O78099 O19799 B2RAK2 Q9UBZ8 Q5GR31 O14499 Q9MY18 B0UZ10 Q861E6 O19802 Q5GR43 O78100 Q5GR42 P79525 O78101
|
| Accessions |
AAB42011 AAB51802 ADL14274 AEH04659 AEH04660 AEK67483 AFC76155 AFR77727 AFR77728 AFR77729 AFR77730 AFR77731 AFR77732 AFR77733 AFR77734 BAA23476 BAA23477 BAA23478 BAA23479 BAA23480 BAA23481 BAA23482 BAA23483 BAA23484 BAA23485 BAB63307 BAC54939 BAE78634 BAF31274 CAB72097 CAB72098 CAB72101 CAD91554 CAE54932 CAE54933 CAE54934 CAE54935 CAE54936 CAE54937 CAE54938 CAE54939 CAE54940 CAE54941 CAE54942 CAE54943 CAE54944 CAE54945 CAE54946 CAE54947 CAE54948 CAE54949 CAE54952 CAE54953 CAE54954 CAE54955 CAE54956 CAE54957 EAX03402 EAX03403 Q29980 AF021221 AAC39846 AF021222 AAC39847 AF021223 AAC39848 AF021224 AAC39849 AF021225 AAC39850 AF021226 AAC39851 AK291927 BAF84616 AK300791 BAG62451 AK303655 BAH14007 AK314228 BAG36899 AY885251 BC044218 AAH44218 BQ216247 BU684700 CN389975 DB121254 DC364717 DC427936 GU235997 ADA68470 U95729 AAB71642 U95730 AAB71643 U95731 AAB71644 U95732 AAB71645 U95733 AAB71646 U95734 AAB71647 X91625 CAA62823 XM_006726002 XP_006726065 XM_006726095 XP_006726158 XM_011514630 XP_011512932 XM_011514631 XP_011512933 XM_011546312 XP_011544614 XM_011546313 XP_011544615 XM_011547251 XP_011545553 XM_011547252 XP_011545554 XM_011547655 XP_011545957 XM_011547656 XP_011545958 XM_011548052 XP_011546354 XM_011548053 XP_011546355 NM_001289160 NP_001276089 NM_001289161 NP_001276090 NM_005931 NP_005922
|
| Function |
Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis. {ECO:0000269|PubMed:11491531, ECO:0000269|PubMed:11777960, ECO:0000269|PubMed:9497295}.
|
| Subcellular Location |
Cell membrane {ECO:0000250|UniProtKB:Q29983}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q29983}. Note=Binding to human cytomegalovirus glycoprotein UL16 causes sequestration in the endoplasmic reticulum. {ECO:0000250|UniProtKB:Q29983, ECO:0000269|PubMed:12782710}.
|
| Tissue Specificity |
Widely expressed with the exception of the central nervous system where it is absent. Expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In hepatocellular carcinomas, expressed in tumor cells but not in surrounding non-cancerous tissue. {ECO:0000269|PubMed:10359807, ECO:0000269|PubMed:12569559, ECO:0000269|PubMed:17565371}.
|
| Top Pathways |
Natural killer cell mediated cytotoxicity
|
