Gene Symbol | TMC1 |
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Entrez Gene | 117531 |
Alt Symbol | DFNA36, DFNB11, DFNB7 |
Species | Human |
Gene Type | protein-coding |
Description | transmembrane channel-like 1 |
Other Description | transmembrane channel-like protein 1|transmembrane cochlear-expressed protein 1|transmembrane, cochlear expressed, 1 |
Swissprots | B1AM91 Q8TDI8 A8MVZ2 |
Accessions | EAW62539 EAW62540 EAW62541 Q8TDI8 AF417578 AAL86399 AK098607 BAC05351 AK307461 BC103955 AAI03956 BC103956 AAI03957 BC114380 AAI14381 BC114449 BC141860 AAI41861 BC156561 AAI56562 BC172523 AAI72523 XM_011518213 XP_011516515 NM_138691 NP_619636 |
Function | Probable ion channel required for the normal function of cochlear hair cells. {ECO:0000250}. |
Subcellular Location | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
Tissue Specificity | Detected in fetal cochlea, and at low levels in placenta and testis. |
TMC1 CRISPR/Cas9 KO Plasmid (h) - sc-414115 from Santa Cruz Biotechnology
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TMC1 HDR Plasmid (h) - sc-414115-HDR from Santa Cruz Biotechnology
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TMC1 Double Nickase Plasmid (h) - sc-414115-NIC from Santa Cruz Biotechnology
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TMC1 Double Nickase Plasmid (h2) - sc-414115-NIC-2 from Santa Cruz Biotechnology
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TMC1 CRISPR Activation Plasmid (h) - sc-414115-ACT from Santa Cruz Biotechnology
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TMC1 CRISPR Activation Plasmid (h2) - sc-414115-ACT-2 from Santa Cruz Biotechnology
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TMC1 Lentiviral Activation Particles (h) - sc-414115-LAC from Santa Cruz Biotechnology
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TMC1 Lentiviral Activation Particles (h2) - sc-414115-LAC-2 from Santa Cruz Biotechnology
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TMC1 siRNA (h) - sc-92928 from Santa Cruz Biotechnology
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TMC1 shRNA Plasmid (h) - sc-92928-SH from Santa Cruz Biotechnology
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TMC1 shRNA (h) Lentiviral Particles - sc-92928-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU059601 from Sigma-Aldrich
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MISSION® esiRNA - EHU101561 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21432 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21432 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04637 from Sigma-Aldrich
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TMC1 siRNA (Human) - CRJ4570 from Cohesion Biosciences
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TMC1 - MBS8232456 from MyBioSource
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shRNA set against Human TMC1 (NM_138691.2) - SHH428340 from Creative biogene
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shRNA set against Human TMC1(NM_138691.2) - SHL074356 from Creative biogene
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Human TMC1 siRNA - orb275071 from Biorbyt
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TMC1 shRNA Plasmid (Human) - CHJ4570 from Cohesion Biosciences
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