Vegfa
| Gene Symbol | Vegfa |
|---|---|
| Entrez Gene | 83785 |
| Alt Symbol | VEGF-A, VEGF164, VPF, Vegf |
| Species | Rat |
| Gene Type | protein-coding |
| Description | vascular endothelial growth factor A |
| Other Description | vascular permeability factor |
| Swissprots | Q9QXG6 Q9JKX7 Q9QXG7 Q91ZE1 P16612 Q541S6 |
| Accessions | EDM18768 EDM18769 EDM18770 EDM18771 EDM18772 EDM18773 EDM18774 EDM18775 EDM18776 EDM18777 EDM18778 EDM18779 EDM18780 EDM18781 EDM18782 EDM18783 EDM18784 EDM18785 EDM18786 EDM18787 EDM18788 P16612 AF062644 AAC16448 AF080594 AAC36708 AF215725 AAF19211 AF215726 AAF19212 AF222779 AAF25958 AF260425 AAK49396 AF261751 AAK49408 AY033503 AAL07523 AY033504 AAL07524 AY033505 AAL07525 AY033506 AAL07526 AY033507 AAL07527 AY033508 AAL07528 AY378102 AY702972 AAU36606 BC168708 AAI68708 BQ203400 CB718631 CB810370 CK357826 CK358638 CK364938 CK602714 CO565920 CV107730 EU040284 ABW02818 EU040285 ABW02819 GQ423618 ACV52076 L20913 AAA42334 M32167 AAA41211 NM_001110333 NP_001103803 NM_001110334 NP_001103804 NM_001110335 NP_001103805 NM_001110336 NP_001103806 NM_001287107 NP_001274036 NM_001287108 NP_001274037 NM_001287110 NP_001274039 NM_001287111 NP_001274040 NM_001287112 NP_001274041 NM_001287113 NP_001274042 NM_001287114 NP_001274043 NM_031836 NP_114024 NR_105011 |
| Function | Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. May play a role in increasing vascular permeability during lactation, when increased transport of molecules from the blood is required for efficient milk protein synthesis. {ECO:0000269|PubMed:10878616}. |
| Subcellular Location | Secreted {ECO:0000250}. Note=VEGF-A120 is acidic and freely secreted. VEGF-A164 is more basic, has heparin- binding properties and, although a signicant proportion remains cell-associated, most is freely secreted. VEGF-A188 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin (By similarity). {ECO:0000250}. |
| Tissue Specificity | Expressed in the pituitary, in brain, in particularly in supraoptic and paraventricular nuclei and the choroid plexus. Also found abundantly in the corpus luteum of the ovary and in kidney glomeruli. Expressed in the ductal epithelial cells of post-pubertal mammary glands. Expressed in the ductal and alveolar epithelial cells throughout the whole period of gestational evolution, lactation and involution. {ECO:0000269|PubMed:10878616}. |
| Top Pathways | Proteoglycans in cancer, MicroRNAs in cancer, Rap1 signaling pathway, Cytokine-cytokine receptor interaction, PI3K-Akt signaling pathway |
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