| Gene Symbol | XRCC3 |
|---|---|
| Entrez Gene | 7517 |
| Alt Symbol | CMM6 |
| Species | Human |
| Gene Type | protein-coding |
| Description | X-ray repair complementing defective repair in Chinese hamster cells 3 |
| Other Description | DNA repair protein XRCC3|X-ray repair cross-complementing protein 3 |
| Swissprots | Q9BU18 O43542 O43568 |
| Accessions | AAC04805 AAM23015 CAE90683 CAE91829 EAW81837 EAW81838 EAW81839 EAW81840 EAW81841 EAW81842 O43542 AF035586 AAC05368 AK022829 BAG51121 AK023646 BAG51212 AK124498 BAG54042 AK126706 BC001036 AAH01036 BC002949 AAH02949 BC011725 AAH11725 BC073820 BT007417 AAP36085 BX161398 CAD61884 DB041321 DQ892162 ABM83088 DQ895355 ABM86281 XM_005268046 XP_005268103 XM_011537138 XP_011535440 NM_001100118 NP_001093588 NM_001100119 NP_001093589 NM_005432 NP_005423 |
| Function | Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2- dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C. {ECO:0000269|PubMed:14716019, ECO:0000269|PubMed:20413593, ECO:0000269|Pu |
| Subcellular Location | Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. Note=Accumulates in discrete nuclear foci prior to DNA damage, and these foci persist throughout the time course of DNA repair. |
| Top Pathways | Homologous recombination |