XRCC3

Gene Symbol XRCC3
Entrez Gene 7517
Alt Symbol CMM6
Species Human
Gene Type protein-coding
Description X-ray repair complementing defective repair in Chinese hamster cells 3
Other Description DNA repair protein XRCC3|X-ray repair cross-complementing protein 3
Swissprots Q9BU18 O43542 O43568
Accessions AAC04805 AAM23015 CAE90683 CAE91829 EAW81837 EAW81838 EAW81839 EAW81840 EAW81841 EAW81842 O43542 AF035586 AAC05368 AK022829 BAG51121 AK023646 BAG51212 AK124498 BAG54042 AK126706 BC001036 AAH01036 BC002949 AAH02949 BC011725 AAH11725 BC073820 BT007417 AAP36085 BX161398 CAD61884 DB041321 DQ892162 ABM83088 DQ895355 ABM86281 XM_005268046 XP_005268103 XM_011537138 XP_011535440 NM_001100118 NP_001093588 NM_001100119 NP_001093589 NM_005432 NP_005423
Function Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2- dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C. {ECO:0000269|PubMed:14716019, ECO:0000269|PubMed:20413593, ECO:0000269|Pu
Subcellular Location Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. Note=Accumulates in discrete nuclear foci prior to DNA damage, and these foci persist throughout the time course of DNA repair.
Top Pathways Homologous recombination

XRCC3 (D-7) - sc-271714 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
XRCC3 (D-7): sc-271714. Western blot analysis of XRCC3 expression in SK-N-MC whole cell lysate.

XRCC3 (E-20) - sc-5905 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

XRCC3 (N-19) - sc-5904 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
XRCC3 (N-19): sc-5904. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear and cytoplasmic localization.

XRCC3 (10F1/6) - sc-53471 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
XRCC3 (10F1/6): sc-53471. Western blot analysis of XRCC3 expression in HeLa nuclear extract under reducing (A) and non-reducing conditions (B).

XRCC3 (H-300) - sc-11430 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-XRCC3 antibody - ab58467 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using ab58467 at a dilution of 1/50. Right hand image: treated with immunising peptide. Left hand image: untreated.

Anti-XRCC3 antibody - ab97390 from Abcam

Prices $378.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-XRCC3 antibody (ab97390) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg

Anti-XRCC3 antibody - ab2368 from Abcam

Prices $372.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal

Anti-XRCC3 antibody - ab103070 from Abcam

Prices $376.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-XRCC3 antibody (ab103070) at 1/250 dilutionLane 1 : HEK293 (Human embryonic kidney cell line) Whole Cell Lysate Lane 2 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLane 3 : HeLa (Human epithelial carcinoma cell line) Nuclear LysateLane 4 : U2OS (Human osteosarcoma cell line) Whole Cell Lysate Lane 5 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) (ab97051) at 1/10000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-XRCC3 antibody - ab172102 from Abcam

Prices $376.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-XRCC3 antibody (ab172102) at 1/500 dilutionLane 1 : Lysate from 293T cells transfected with XRCC3Lane 2 : Lysate from untransfected 293T cellsLysates/proteins at 15 µl per lane.

Anti-XRCC3 antibody - ab184687 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-XRCC3 antibody (ab184687) at 1/500 dilution + H1299 whole cell lysate at 30 µg

Anti-XRCC3 antibody [10F1/6] (HRP) - ab187814 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 10F1/6

Anti-XRCC3 antibody [EPR4678(2)] - ab133736 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4678(2)
All lanes : Anti-XRCC3 antibody [EPR4678(2)] (ab133736) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : HepG2 cell lysateLane 3 : 293T cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP-conjugated goat anti-rabbit at 1/2000 dilution

Anti-XRCC3 antibody [XRCC3 10F1/6] - ab20254 from Abcam

Prices $387.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone XRCC3 10F1/6
Ab20254 staining human normal placenta. Staining is localized to nuclear compartment.Left panel: with primary antibody at 4 ug/ml. Right panel: isotype control.Sections were stained using an automated system DAKO Autostainer Plus , at room temperature. Sections were rehydrated and antigen retrieved with the Dako 3-in-1 AR buffer EDTA pH 9.0 in a DAKO PT Link. Slides were peroxidase blocked in 3% H2O2 in methanol for 10 minutes. They were then blocked with Dako Protein block for 10 minutes (containing casein 0.25% in PBS) then incubated with primary antibody for 20 minutes and detected with Dako Envision Flex amplification kit for 30 minutes. Colorimetric detection was completed with Diaminobenzidine for 5 minutes. Slides were counterstained with Haematoxylin and coverslipped under DePeX. Please note that for manual staining we recommend to optimize the primary antibody concentration and incubation time (overnight incubation), and amplification may be required.

Anti-XRCC3 Antibody (aa152-182) - LS-C160671 from LifeSpan Bioscience

Prices $250.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
XRCC3 Antibody (Center) IHC of formalin fixed and paraffin embedded human lymph tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This demonstrates the use of the XRCC3 Antibody (Center) for immunohistochemistry.

Anti-XRCC3 Antibody - LS-C11109 from LifeSpan Bioscience

Prices $355.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-XRCC3 Antibody - LS-C20087 from LifeSpan Bioscience

Prices $275.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

Anti-XRCC3 Antibody (aa69-81) - LS-C90777 from LifeSpan Bioscience

Prices $530.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-XRCC3 Antibody (N-Terminus) - LS-C95917 from LifeSpan Bioscience

Prices $415.00, $690.00
Sizes 500 µl, 1 ml
Host Rabbit
Clonality Polyclonal

Anti-XRCC3 Antibody (DY488) - LS-C140843 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-XRCC3 Antibody (DY650) - LS-C140842 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-XRCC3 Antibody (Biotin) - LS-C140841 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-XRCC3 Antibody (HRP) - LS-C140844 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-XRCC3 Antibody (DY550) - LS-C140845 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-XRCC3 Antibody (clone 10F1/6, DY650) - LS-C140872 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 10F1/6
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