| Gene Symbol |
MORF4L2
|
| Entrez Gene |
9643
|
| Alt Symbol |
MORFL2, MRGX
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mortality factor 4 like 2
|
| Other Description |
MORF-related gene X protein|MSL3-2 protein|mortality factor 4-like protein 2|protein MSL3-2|transcription factor-like protein MRGX
|
| Swissprots |
Q567V0 Q15014 B3KP92 Q8J026 D3DXA5
|
| Accessions |
EAW54697 EAW54698 EAW54699 EAW54700 EAW54701 Q15014 AB050778 BAC22659 AB050779 AF100620 AAD29873 AF167174 AAF80855 AK056012 BAG51604 AK095298 AK126115 BAG54288 AK126427 BAG54326 AK223504 BAD97224 AK302083 BAG63470 BC056899 AAH56899 BC093013 AAH93013 BM471743 BM835303 D14812 BAA03553 DA068448 DA268606 DA987770 DC301727 DC366195 DC419967 DC424668 EU446748 ABZ92277 EU832807 ACE87818 GQ129427 ACT64561 NM_001142418 NP_001135890 NM_001142419 NP_001135891 NM_001142420 NP_001135892 NM_001142421 NP_001135893 NM_001142422 NP_001135894 NM_001142423 NP_001135895 NM_001142424 NP_001135896 NM_001142425 NP_001135897 NM_001142426 NP_001135898 NM_001142427 NP_001135899 NM_001142428 NP_001135900 NM_001142429 NP_001135901 NM_001142430 NP_001135902 NM_001142431 NP_001135903 NM_001142432 NP_001135904 NM_012286 NP_036418
|
| Function |
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones.
|
| Subcellular Location |
Nucleus.
|
![Western Blot: MORF4L2 Overexpression Lysate (Adult Normal) [NBL1-13184] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MORF4L2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7913_MORF4L2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-13184-img0002.jpg)