Gene Symbol | CCDC109B |
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Entrez Gene | 55013 |
Alt Symbol | MCUb |
Species | Human |
Gene Type | protein-coding |
Description | coiled-coil domain containing 109B |
Other Description | calcium uniporter regulatory subunit MCUb, mitochondrial|coiled-coil domain-containing protein 109B|mitochondrial calcium uniporter regulatory subunit MCUb |
Swissprots | Q9NWR8 Q6IAC1 A8K4Y3 |
Accessions | EAX06242 EAX06243 Q9NWR8 AK000654 BAA91309 AK095936 AK291098 BAF83787 AK311030 AL832311 BC002633 AAH02633 BM830891 CN427680 CR457234 CAG33515 HQ447337 ADQ31823 XM_006714246 XP_006714309 NM_017918 NP_060388 |
Function | Negatively regulates the activity of MCU, the mitochondrial inner membrane calcium uniporter, and thereby modulates calcium uptake into the mitochondrion. Does not form functional calcium channels by itself. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. {ECO:0000250|UniProtKB:Q810S1}. |
Subcellular Location | Mitochondrion inner membrane {ECO:0000269|PubMed:24231807}; Multi-pass membrane protein {ECO:0000269|PubMed:24231807}. |
CCDC109B CRISPR/Cas9 KO Plasmid (h) - sc-412415 from Santa Cruz Biotechnology
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CCDC109B HDR Plasmid (h) - sc-412415-HDR from Santa Cruz Biotechnology
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CCDC109B Double Nickase Plasmid (h) - sc-412415-NIC from Santa Cruz Biotechnology
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CCDC109B Double Nickase Plasmid (h2) - sc-412415-NIC-2 from Santa Cruz Biotechnology
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CCDC109B CRISPR Activation Plasmid (h) - sc-412415-ACT from Santa Cruz Biotechnology
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CCDC109B CRISPR Activation Plasmid (h2) - sc-412415-ACT-2 from Santa Cruz Biotechnology
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CCDC109B Lentiviral Activation Particles (h) - sc-412415-LAC from Santa Cruz Biotechnology
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CCDC109B Lentiviral Activation Particles (h2) - sc-412415-LAC-2 from Santa Cruz Biotechnology
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CCDC109B siRNA (h) - sc-89301 from Santa Cruz Biotechnology
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CCDC109B shRNA Plasmid (h) - sc-89301-SH from Santa Cruz Biotechnology
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CCDC109B shRNA (h) Lentiviral Particles - sc-89301-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU143541 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5454 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5454 from Sigma-Aldrich
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CCDC109B siRNA (Human) - CRJ0406 from Cohesion Biosciences
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CCDC109B - MBS8201716 from MyBioSource
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shRNA set against Human CCDC109B (NM_017918.4) - SHH255801 from Creative biogene
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CCDC109B shRNA Plasmid (Human) - CHJ0406 from Cohesion Biosciences
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CCDC109B miRNA 3'UTR clone - MiUTR3H-14303 from Creative biogene
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