PDE8B
| Gene Symbol | PDE8B |
|---|---|
| Entrez Gene | 8622 |
| Alt Symbol | ADSD, PPNAD3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | phosphodiesterase 8B |
| Other Description | 3',5' cyclic nucleotide phosphodiesterase 8B|cell proliferation-inducing gene 22 protein|high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B|hsPDE8B |
| Swissprots | Q8N3T2 Q86XK8 Q8IUK0 O95263 Q8IUJ7 Q8IUJ9 Q5J7V7 Q8IUJ8 |
| Accessions | AAN71725 AAN71726 AAN71727 EAW95798 EAW95799 EAW95800 EAW95801 EAW95802 EAW95803 EAW95804 O95263 AB085824 BAC53762 AB085825 BAC53763 AB085826 BAC53764 AB085827 BAC53765 AF079529 AAC69564 AK002074 BAG51011 AK023913 BAG51239 AL831924 CAD38584 AY129948 AAN71723 AY129949 AAN71724 AY423729 AAS00492 BC035144 AAH35144 BC043209 BC047627 AAH47627 BC156215 AAI56216 BC156987 AAI56988 BE169437 BF109581 BI005015 BI677296 BU071384 XM_005248621 XP_005248678 XM_005248623 XP_005248680 XM_005248624 XP_005248681 XM_006714725 XP_006714788 XM_006714726 XP_006714789 XM_011543699 XP_011542001 XM_011543700 XP_011542002 XM_011543701 XP_011542003 XM_011543702 XP_011542004 XM_011543703 XP_011542005 XM_011543704 XP_011542006 NM_001029851 NP_001025022 NM_001029852 NP_001025023 NM_001029853 NP_001025024 NM_001029854 NP_001025025 NM_003719 NP_003710 |
| Function | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland. |
| Tissue Specificity | Abundantly expressed in the thyroid. Also very weakly expressed in brain, spinal cord and placenta. In the thyroid isoform 1 predominates, and isoforms 2 and 6 are also highly expressed. In the placenta isoforms 1 and 2 are expressed equally. In the brain isoform 2 predominates. {ECO:0000269|PubMed:12372422, ECO:0000269|PubMed:12681444}. |
| Top Pathways | Morphine addiction, Purine metabolism |
PDE8B CRISPR/Cas9 KO Plasmid (h) - sc-404554 from Santa Cruz Biotechnology
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PDE8B HDR Plasmid (h) - sc-404554-HDR from Santa Cruz Biotechnology
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PDE8B Double Nickase Plasmid (h) - sc-404554-NIC from Santa Cruz Biotechnology
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PDE8B Double Nickase Plasmid (h2) - sc-404554-NIC-2 from Santa Cruz Biotechnology
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PDE8B CRISPR Activation Plasmid (h) - sc-404554-ACT from Santa Cruz Biotechnology
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PDE8B CRISPR Activation Plasmid (h2) - sc-404554-ACT-2 from Santa Cruz Biotechnology
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PDE8B Lentiviral Activation Particles (h) - sc-404554-LAC from Santa Cruz Biotechnology
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PDE8B Lentiviral Activation Particles (h2) - sc-404554-LAC-2 from Santa Cruz Biotechnology
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PDE8B siRNA (h) - sc-41618 from Santa Cruz Biotechnology
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PDE8B shRNA Plasmid (h) - sc-41618-SH from Santa Cruz Biotechnology
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PDE8B shRNA (h) Lentiviral Particles - sc-41618-V from Santa Cruz Biotechnology
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PDE8B RNAi - H00008622-R04 from Novus Biologicals
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PDE8B RNAi - H00008622-R01 from Novus Biologicals
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PDE8B RNAi - H00008622-R03 from Novus Biologicals
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MISSION® esiRNA - EHU090981 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2173 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2173 from Sigma-Aldrich
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PDE8B siRNA (Human) - CRH5665 from Cohesion Biosciences
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PDE8B RNAi - H00008622-R05 from Novus Biologicals
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PDE8B RNAi - H00008622-R02 from Novus Biologicals
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shRNA set against Human PDE8B (NM_003719.3) - SHH372604 from Creative biogene
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Human PDE8B siRNA - orb266167 from Biorbyt
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PDE8B shRNA Plasmid (Human) - CHH5665 from Cohesion Biosciences
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PDE8B miRNA 3'UTR clone - MiUTR3H-05921 from Creative biogene
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PDE8B miRNA 3'UTR clone - MiUTR3H-05922 from Creative biogene
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