Nbn

Gene Symbol Nbn
Entrez Gene 27354
Alt Symbol Nbs1
Species Mouse
Gene Type protein-coding
Description nibrin
Other Description cell cycle regulatory protein p95|nijmegen breakage syndrome protein 1 homolog
Swissprots Q9R1X1 Q811I6 O88981 Q9R207 Q8CCY0 Q3UY57
Accessions EDL05594 Q9R207 AB016988 BAA76298 AF076687 AAD20943 AF092840 AAC62113 AK031933 BAC27610 AK132302 AK134805 AK134960 BAE22356 AK159790 AK160614 AK183777 AK206526 AK214489 BC003719 BC013190 BC044773 AAH44773 BC055061 AAH55061 XM_006537970 XP_006538033 XM_006537971 XP_006538034 NM_013752 NP_038780
Function Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of
Subcellular Location Nucleus. Nucleus, PML body {ECO:0000250}. Chromosome, telomere {ECO:0000250}. Note=Localizes to discrete nuclear foci after treatment with genotoxic agents. {ECO:0000250}.
Tissue Specificity High expression in the liver, heart and testis. Low expression in all other tissues analyzed. In the cerebellum the postmitotic Purkinje cells are marked specifically. {ECO:0000269|PubMed:10915761}.
Top Pathways Homologous recombination

Nbs1 Antibody - NBP1-06609 from Novus Biologicals

Prices $99.00, $279.00
Sizes 25 µl, 100 µl
Host Rabbit
Clonality Polyclonal

Nbs1 Antibody - NBP1-06705 from Novus Biologicals

Prices $99.00, $279.00
Sizes 25 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: NBS1 Antibody [NBP1-06705] - Western Blot on NIH/3T3 (Lane 6) and HeLa whole cell extract (Lane 7).

Nbs1 Antibody - NB100-60648 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: NBS1 Antibody [NB100-60648] - Detection of Mouse NBS1 on HeLa whole cell lysate using NB100-60648. NBS1 was also immunoprecipitated by another rabbit anti-NBS1 antibody.

Nbs1 Antibody [DyLight 650] - NBP1-06705C from Novus Biologicals

Prices $319.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Nbs1 Antibody [DyLight 550] - NBP1-06609R from Novus Biologicals

Prices $319.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Nbs1 Antibody [Biotin] - NBP1-06705B from Novus Biologicals

Prices $299.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Nbs1 Antibody [HRP] - NBP1-06705H from Novus Biologicals

Prices $319.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Nbs1 Antibody [DyLight 488] - NBP1-06705G from Novus Biologicals

Prices $319.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Nbs1 Antibody [DyLight 550] - NBP1-06705R from Novus Biologicals

Prices $319.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Nbs1 Antibody [HRP] - NBP1-06609H from Novus Biologicals

Prices $319.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Nbs1 Antibody [DyLight 488] - NBP1-06609G from Novus Biologicals

Prices $319.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Nbs1 Antibody [Biotin] - NBP1-06609B from Novus Biologicals

Prices $299.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Nbs1 Antibody [DyLight 650] - NBP1-06609C from Novus Biologicals

Prices $319.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Nbs1 Antibody [DyLight 405] - NBP1-06705V from Novus Biologicals

Prices $319.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Nbs1 Antibody [DyLight 405] - NBP1-06609V from Novus Biologicals

Prices $319.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Nbs1 Antibody [FITC] - NBP1-06705F from Novus Biologicals

Prices $299.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Nbs1 Antibody [FITC] - NBP1-06609F from Novus Biologicals

Prices $299.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Nbs1 Antibody [Alexa Fluor (R) 700] - NBP1-06705AF700 from Novus Biologicals

Prices $319.00
Sizes 100 tests
Host Rabbit
Clonality Polyclonal

Nbs1 Antibody [Alexa Fluor (R) 647] - NBP1-06705AF647 from Novus Biologicals

Prices $319.00
Sizes 100 tests
Host Rabbit
Clonality Polyclonal

Nbs1 Antibody [Alexa Fluor (R) 488] - NBP1-06705AF488 from Novus Biologicals

Prices $329.00
Sizes 100 tests
Host Rabbit
Clonality Polyclonal

Nbs1 Antibody [Alexa Fluor (R) 405] - NBP1-06705AF405 from Novus Biologicals

Prices $319.00
Sizes 100 tests
Host Rabbit
Clonality Polyclonal

Nbs1 Antibody [Alexa Fluor (R) 700] - NBP1-06609AF700 from Novus Biologicals

Prices $319.00
Sizes 100 tests
Host Rabbit
Clonality Polyclonal

Nbs1 Antibody [Alexa Fluor (R) 647] - NBP1-06609AF647 from Novus Biologicals

Prices $319.00
Sizes 100 tests
Host Rabbit
Clonality Polyclonal

Nbs1 Antibody [Alexa Fluor (R) 488] - NBP1-06609AF488 from Novus Biologicals

Prices $329.00
Sizes 100 tests
Host Rabbit
Clonality Polyclonal

Nbs1 Antibody [Alexa Fluor (R) 405] - NBP1-06609AF405 from Novus Biologicals

Prices $319.00
Sizes 100 tests
Host Rabbit
Clonality Polyclonal
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