Gene Symbol | CYP2E1 |
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Entrez Gene | 1571 |
Alt Symbol | CPE1, CYP2E, P450-J, P450C2E |
Species | Human |
Gene Type | protein-coding |
Description | cytochrome P450, family 2, subfamily E, polypeptide 1 |
Other Description | 4-nitrophenol 2-hydroxylase|CYPIIE1|cytochrome P450 2E1|cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1|cytochrome P450-J|flavoprotein-linked monooxygenase|microsomal monooxygenase|xenobiotic monooxygenase |
Swissprots | Q5VZD5 Q6NWT9 P05181 Q9UK47 |
Accessions | AAA52155 ABF47105 BAA00902 BAA08796 EAW61357 EAW61358 P05181 AF084225 AAD13753 AF182276 AAF13601 AJ853939 CAH69381 AJ853940 CAH69382 AJ877238 CAI47002 AK290822 BAF83511 BC067433 AAH67433 BC067435 AAH67435 BX951478 DQ149222 AAZ77710 J02625 AAA35743 S77873 AAD14267 NM_000773 NP_000764 |
Function | Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms. |
Subcellular Location | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. |
Top Pathways | Steroid hormone biosynthesis, Chemical carcinogenesis, Non-alcoholic fatty liver disease (NAFLD), Arachidonic acid metabolism, Linoleic acid metabolism |
CYP2E1 CRISPR/Cas9 KO Plasmid (h) - sc-401357 from Santa Cruz Biotechnology
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CYP2E1 HDR Plasmid (h) - sc-401357-HDR from Santa Cruz Biotechnology
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CYP2E1 Double Nickase Plasmid (h) - sc-401357-NIC from Santa Cruz Biotechnology
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CYP2E1 Double Nickase Plasmid (h2) - sc-401357-NIC-2 from Santa Cruz Biotechnology
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CYP2E1 CRISPR Activation Plasmid (h) - sc-401357-ACT from Santa Cruz Biotechnology
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CYP2E1 CRISPR Activation Plasmid (h2) - sc-401357-ACT-2 from Santa Cruz Biotechnology
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CYP2E1 Lentiviral Activation Particles (h) - sc-401357-LAC from Santa Cruz Biotechnology
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CYP2E1 Lentiviral Activation Particles (h2) - sc-401357-LAC-2 from Santa Cruz Biotechnology
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CYP2E1 siRNA (h) - sc-105257 from Santa Cruz Biotechnology
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CYP2E1 shRNA Plasmid (h) - sc-105257-SH from Santa Cruz Biotechnology
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CYP2E1 shRNA (h) Lentiviral Particles - sc-105257-V from Santa Cruz Biotechnology
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Cytochrome P450 2E1 RNAi - H00001571-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN1804 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1804 from Sigma-Aldrich
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CYP2E1 siRNA (Human) - CRH1103 from Cohesion Biosciences
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CYP2E1 - MBS828817 from MyBioSource
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shRNA set against Human CYP2E1 (NM_000773.3) - SHH273297 from Creative biogene
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shRNA set against Human CYP2E1(NM_000773.3) - SHG217051 from Creative biogene
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Human CYP2E1 siRNA - orb261605 from Biorbyt
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CYP2E1 shRNA Plasmid (Human) - CHH1103 from Cohesion Biosciences
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CYP2E1 miRNA 3'UTR clone - MiUTR1H-02623 from Creative biogene
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