| Gene Symbol |
MEIS2
|
| Entrez Gene |
4212
|
| Alt Symbol |
HsT18361, MRG1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Meis homeobox 2
|
| Other Description |
Meis homolog 2|Meis1, myeloid ecotropic viral integration site 1 homolog 2|Meis1-related gene 1|TALE homeobox protein Meis2|homeobox protein Meis2|meis1-related protein 1
|
| Swissprots |
Q9NRS1 B3KPQ6 A8MWD5 Q96KI5 O14770 Q96DI2 Q96KI4 Q9NRS3 A6NJI5 B3KP98 Q9NRS2
|
| Accessions |
EAW92343 EAW92344 EAW92345 EAW92346 EAW92347 EAW92348 EAW92349 EAW92350 EAW92351 EAW92352 EAW92353 EAW92354 EAW92355 EAW92356 EAW92357 EAW92358 O14770 AF017418 AAB70270 AF178948 AAF81638 AF179896 AAF81639 AF179897 AAF81640 AF179898 AAF81641 AF179899 AAF81642 AK001298 AK055936 BAG51593 AK056038 BAG51610 AK056216 BAG51650 AK056620 BAG51768 AK094531 AK226072 AK294411 BAH11758 AK300247 BAH13242 AK311546 AY349358 AAQ56722 BC001516 AAH01516 BC001844 AAH01844 BC007202 AAH07202 BC050431 AAH50431 BM679305 DA648763 DA689122 EU446635 ABZ92164 EU831754 ACE87272 EU831824 ACE86583 EU831831 ACE86590 XM_006720522 XP_006720585 XM_006720523 XP_006720586 XM_006720524 XP_006720587 XM_006720525 XP_006720588 XM_006720526 XP_006720589 XM_006720527 XP_006720590 XM_006720528 XP_006720591 XM_006720529 XP_006720592 XM_011521591 XP_011519893 NM_001220482 NP_001207411 NM_002399 NP_002390 NM_170674 NP_733774 NM_170675 NP_733775 NM_170676 NP_733776 NM_170677 NP_733777 NM_172315 NP_758526 NM_172316 NP_758527 NR_051953 NM_020149
|
| Function |
Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3/Meis2B is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3/Meis2B and isoform 4/Meis2D can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TG
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108}.
|
| Tissue Specificity |
Expressed in various tissues. Expressed at high level in the lymphoid organs of hematopoietic tissues. Also expressed in some regions of the brain, such as the putamen.
|