| Gene Symbol |
TCEB1
|
| Entrez Gene |
6921
|
| Alt Symbol |
SIII, eloC
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
|
| Other Description |
RNA polymerase II transcription factor SIII subunit C|SIII p15|elongin 15 kDa subunit|transcription elongation factor B polypeptide 1
|
| Swissprots |
Q15369 E5RGD9 Q567Q6
|
| Accessions |
EAW87015 EAW87016 EAW87017 EAW87018 EAW87019 EAW87020 EAW87021 Q15369 AK057889 AL832244 BC013809 AAH13809 BC093065 AAH93065 BC100028 AAI00029 BC100283 AAI00284 BG428202 BG703267 BG767430 BM720777 BM821650 BX649138 CF129635 CX166168 CX166843 DA537957 DQ894197 ABM85123 EU176247 ABW03698 L34587 AAA67650 XM_011517580 XP_011515882 XM_011517581 XP_011515883 NM_001204857 NP_001191786 NM_001204858 NP_001191787 NM_001204859 NP_001191788 NM_001204860 NP_001191789 NM_001204861 NP_001191790 NM_001204862 NP_001191791 NM_001204863 NP_001191792 NM_001204864 NP_001191793 NM_005648 NP_005639
|
| Function |
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). {ECO:0000269|PubMed:15590694}.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|
| Tissue Specificity |
Overexpressed in prostate cancer cell line PC- 3 and breast cancer cell line SK-BR-3. {ECO:0000269|PubMed:12004003}.
|
| Top Pathways |
Ubiquitin mediated proteolysis, Renal cell carcinoma
|