| Gene Symbol | Ank3 |
|---|---|
| Entrez Gene | 11735 |
| Alt Symbol | 2900054D09Rik, AI314020, Ank-3, AnkG, Ankyrin-3, Ankyrin-G |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | ankyrin 3, epithelial |
| Other Description | ankyrin-3|brain-specific ankyrin-G |
| Swissprots | Q61305 G5E8K4 Q61308 Q8VC68 Q4U256 Q61310 Q3TSJ8 Q61309 O08866 O08867 Q4U206 Q61307 Q8CBN3 Q4U205 G5E8K5 Q4U260 Q61306 |
| Accessions | AAD29415 BAB39357 CDM21876 CDM21877 EDL31983 EDL31984 EDL31985 EDL31986 EDL31987 EDL31988 EDL31989 EDL31990 EDL31991 EDL31992 EDL31993 EDL31994 G5E8K5 AF212924 AAF18477 AK013684 AK017639 AK033389 BAC28262 AK033919 AK035262 AK035681 BAC29151 AK036171 AK042330 AK081055 AK090087 BAC41086 AK136830 BAE23139 AK139233 AK141720 AK157735 AK162007 BAE36677 AK162547 BB652096 BC021657 AAH21657 BC026152 BC062122 L40631 AAB01602 L40632 AAB01607 U89274 AAB58380 U89275 AAB58381 XM_006513122 XP_006513185 XM_006513124 XP_006513187 XM_006513125 XP_006513188 XM_006513126 XP_006513189 XM_006513127 XP_006513190 XM_006513128 XP_006513191 XM_006513129 XP_006513192 XM_006513130 XP_006513193 XM_006513133 XP_006513196 XM_006513134 XP_006513197 XM_006513135 XP_006513198 XM_006513136 XP_006513199 XM_006513137 XP_006513200 XM_006513138 XP_006513201 XM_006513139 XP_006513202 XM_011243290 XP_011241592 XM_011243291 XP_011241593 XM_011243292 XP_011241594 XM_011243293 XP_011241595 XM_011243294 XP_011241596 XM_011243295 XP_011241597 XM_011243296 XP_011241598 XM_011243297 XP_011241599 XM_011243298 XP_011241600 XM_011243299 XP_011241601 XM_011243300 XP_011241602 XM_011243301 XP_011241603 XM_011243302 XP_011241604 XM_011243303 XP_011241605 XM_011243304 XP_011241606 XM_011243305 XP_011241607 XM_011243306 XP_011241608 XM_011243307 XP_011241609 XM_011243308 XP_011241610 XM_011243309 XP_011241611 XM_011243310 XP_011241612 XM_011243311 XP_011241613 XM_011243312 XP_011241614 XM_011243313 XP_011241615 XM_011243314 XP_011241616 XM_011243315 XP_011241617 XM_011243316 XP_011241618 XM_011243317 XP_011241619 NM_009670 NP_033800 NM_146005 NP_666117 NM_170687 NP_733788 NM_170688 NP_733789 NM_170689 NP_733790 NM_170690 NP_733791 NM_170728 NP_733924 NM_170729 NP_733925 NM_170730 NP_733926 |
| Function | Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (By similarity). In skeletal muscle, required for costamere localization of DMD and betaDAG1. Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). {ECO:0000250, ECO:0000269|PubMed:19109891, ECO:0000269|PubMed:23903368}. |
| Subcellular Location | Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, axon {ECO:0000250}. Cell membrane, sarcolemma. Cell junction, synapse, postsynaptic cell membrane. Lysosome. Note=In skeletal muscle, localized at costameres and neuromuscular junctions. In bone marrow-derived macrophages, isoforms 2 and 3 are associated with lysosomes. |
| Tissue Specificity | Expressed in many epithelial tissues, muscles and axons. Expressed in kidney, brain, skin, lung, liver, intestine, pancreas, heart and testis (at protein level). In testis, expressed in Leydig cells, but very weakly or not at all in Sertoli cells or seminiferous tubules. Expressed in macrophages (at protein level). {ECO:0000269|PubMed:23903368, ECO:0000269|PubMed:7615634, ECO:0000269|PubMed:9060470}. |
| Top Pathways | Proteoglycans in cancer |
Ankyrin G CRISPR/Cas9 KO Plasmid (m) - sc-419109 from Santa Cruz Biotechnology
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Ankyrin G HDR Plasmid (m) - sc-419109-HDR from Santa Cruz Biotechnology
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Ankyrin G Double Nickase Plasmid (m) - sc-419109-NIC from Santa Cruz Biotechnology
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Ankyrin G Double Nickase Plasmid (m2) - sc-419109-NIC-2 from Santa Cruz Biotechnology
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Ankyrin G CRISPR Activation Plasmid (m) - sc-419109-ACT from Santa Cruz Biotechnology
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Ankyrin G CRISPR Activation Plasmid (m2) - sc-419109-ACT-2 from Santa Cruz Biotechnology
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Ankyrin G Lentiviral Activation Particles (m) - sc-419109-LAC from Santa Cruz Biotechnology
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Ankyrin G Lentiviral Activation Particles (m2) - sc-419109-LAC-2 from Santa Cruz Biotechnology
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Ankyrin G siRNA (m) - sc-43268 from Santa Cruz Biotechnology
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Ankyrin G shRNA Plasmid (m) - sc-43268-SH from Santa Cruz Biotechnology
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Ankyrin G shRNA (m) Lentiviral Particles - sc-43268-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU020961 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN26677 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND26677 from Sigma-Aldrich
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ANK3 siRNA (Mouse) - CRM0167 from Cohesion Biosciences
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ANK3 - MBS8209313 from MyBioSource
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shRNA set against Mouse Ank3 (NM_170730.2) - SHH236370 from Creative biogene
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shRNA set against Mouse Ank3(NM_170687.3) - SHG058627 from Creative biogene
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shRNA set against Mouse Ank3(NM_170690.2) - SHG058645 from Creative biogene
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shRNA set against Mouse Ank3(NM_170730.2) - SHG058663 from Creative biogene
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shRNA set against Mouse Ank3(NM_170688.2) - SHG058735 from Creative biogene
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shRNA set against Mouse Ank3(NM_170728.2) - SHG058789 from Creative biogene
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ANK3 shRNA Plasmid (Mouse) - CHM0167 from Cohesion Biosciences
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ANK3 miRNA 3'UTR clone - MiUTR1M-01468 from Creative biogene
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ANK3 miRNA 3'UTR clone - MiUTR1M-01469 from Creative biogene
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