Gene Symbol | TMC2 |
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Entrez Gene | 117532 |
Alt Symbol | C20orf145, dJ686C3.3 |
Species | Human |
Gene Type | protein-coding |
Description | transmembrane channel-like 2 |
Other Description | transmembrane channel-like protein 2|transmembrane cochlear-expressed protein 2|transmembrane, cochlear expressed, 2 |
Swissprots | Q6UWW4 Q9BYN5 Q9BYN2 Q8N9F3 Q9BYN4 Q6ZS41 Q5JXT0 Q5JXT1 Q9BYN3 Q8TDI7 |
Accessions | EAX10591 EAX10592 EAX10593 Q8TDI7 AF417580 AAL86401 AK094789 BAC04423 AK127751 AK294013 BAG57374 AK309782 AK316261 BAH14632 AY358613 AAQ88976 BC111450 AAI11451 DA769512 XM_005260660 XP_005260717 XM_011529153 XP_011527455 NM_080751 NP_542789 |
Function | Probable ion channel required for the normal function of cochlear hair cells. {ECO:0000269|PubMed:11850618}. |
Subcellular Location | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
Tissue Specificity | Detected in fetal cochlea. |
TMC2 CRISPR/Cas9 KO Plasmid (h) - sc-409136 from Santa Cruz Biotechnology
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TMC2 HDR Plasmid (h) - sc-409136-HDR from Santa Cruz Biotechnology
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TMC2 Double Nickase Plasmid (h) - sc-409136-NIC from Santa Cruz Biotechnology
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TMC2 Double Nickase Plasmid (h2) - sc-409136-NIC-2 from Santa Cruz Biotechnology
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TMC2 CRISPR Activation Plasmid (h) - sc-409136-ACT from Santa Cruz Biotechnology
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TMC2 CRISPR Activation Plasmid (h2) - sc-409136-ACT-2 from Santa Cruz Biotechnology
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TMC2 Lentiviral Activation Particles (h) - sc-409136-LAC from Santa Cruz Biotechnology
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TMC2 Lentiviral Activation Particles (h2) - sc-409136-LAC-2 from Santa Cruz Biotechnology
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TMC2 siRNA (h) - sc-76678 from Santa Cruz Biotechnology
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TMC2 shRNA Plasmid (h) - sc-76678-SH from Santa Cruz Biotechnology
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TMC2 shRNA (h) Lentiviral Particles - sc-76678-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU066001 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21433 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21433 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03445 from Sigma-Aldrich
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TMC2 siRNA (Human) - CRJ4571 from Cohesion Biosciences
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TMC2 - MBS8227833 from MyBioSource
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shRNA set against Human TMC2 (NM_080751.2) - SHH428352 from Creative biogene
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shRNA set against Human TMC2(NM_080751.2) - SHL074334 from Creative biogene
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Human TMC2 siRNA - orb275072 from Biorbyt
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TMC2 shRNA Plasmid (Human) - CHJ4571 from Cohesion Biosciences
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TMC2 miRNA 3'UTR clone - MiUTR1H-10454 from Creative biogene
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