| Gene Symbol |
PRMT5
|
| Entrez Gene |
10419
|
| Alt Symbol |
HRMT1L5, IBP72, JBP1, SKB1, SKB1Hs
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein arginine methyltransferase 5
|
| Other Description |
72 kDa ICln-binding protein|HMT1 hnRNP methyltransferase-like 5|SKB1 homolog|histone-arginine N-methyltransferase PRMT5|jak-binding protein 1|protein arginine N-methyltransferase 5|shk1 kinase-binding protein 1 homolog
|
| Swissprots |
Q9UKH1 E2QRE7 D3DS33 O14744 B4DY30 A8MZ91 B5BU10 A8MTP3 B4DX49 Q6IBR1
|
| Accessions |
CAF86569 CAW36507 CAW36522 CAW47075 CAW47090 CAW52884 CAW52899 CAW54329 CAW54344 CAW56663 CAW56678 CAW56884 CAW56899 CAW58130 CAW58145 CAW63380 CAW63395 CAW67682 CAW67697 CAW71688 CAW71703 CAW75488 CAW75503 CAW76906 CAW76921 CAW80180 CAW80195 CAW83710 CAW83725 CAW85688 CAW85725 CAW88052 CAW88087 CBC02460 CBC02475 CBC12707 CBC12736 CBC24395 CBC24426 CBC27261 CBC27290 CBC31963 CBC31992 CBC32400 CBC32427 CBC34850 CBC34879 CBC45305 CBC45335 CBC53883 CBC53913 CBC61885 CBC61915 CBC69422 CBC69455 CBC72246 CBC72276 CBC78810 CBC78840 CBC85871 CBC85900 CBC88583 CBC88615 CBC90649 CBC90681 CBD29472 CBD29487 EAW66217 EAW66218 EAW66219 EAW66220 EAW66221 O14744 AA496357 AB451246 BAG70060 AB451370 BAG70184 AF015913 AAB66581 AF167572 AAF04502 AK027737 AK075251 BAG52095 AK300863 BAG62512 AK301812 BAG63261 AK302240 BAG63592 AK315500 BAG37884 AL833612 BC005820 BC025979 AAH25979 CR456741 CAG33022 DC395183 DQ893421 ABM84347 DQ896773 ABM87772 XR_429287 NM_001039619 NP_001034708 NM_001282953 NP_001269882 NM_001282954 NP_001269883 NM_001282955 NP_001269884 NM_001282956 NP_001269885 NM_006109 NP_006100
|
| Function |
Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. May regulate the SUPT5H transcriptional elongation properties. May be part of a pathway that is connected to a chloride current, possibly through cytoskeletal rearrangement. Methylates histone H2A and H4 'Arg-3' during germ cell development. Methylates histone H3 'Arg-8', which may rep
|
| Subcellular Location |
Cytoplasm. Nucleus.
|
| Tissue Specificity |
Ubiquitous.
|
| Top Pathways |
RNA transport
|
![Western Blot: PRMT5 Overexpression Lysate (Adult Normal) [NBL1-14795] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PRMT5.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3348_PRMT5%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14795-img0002.jpg)