| Gene Symbol |
Lpcat4
|
| Entrez Gene |
99010
|
| Alt Symbol |
AI505034, Agpat7, Aytl3, LPEAT2
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
lysophosphatidylcholine acyltransferase 4
|
| Other Description |
-acylglycerol-3-phosphate O-acyltransferase 7 (lysophosphatidic acid acyltransferase, eta)|1-AGP acyltransferase 7|1-AGPAT 7|1-acylglycerol-3-phosphate O-acyltransferase 7 (lysophosphatidic acid acyltransferase, eta)|1-acylglycerophosphocholine O-acyltransferase|1-acylglycerophosphoserine O-acyltransferase|1-alkenylglycerophosphoethanolamine O-acyltransferase|1-alkylglycerophosphocholine O-acetyltransferase|acyltransferase like 3|acyltransferase-like 3|lysophosphatidylethanolamine acyltransferase 2|lysophospholipid acyltransferase LPCAT4|plasmalogen synthase
|
| Swissprots |
Q6NVG1 Q66JP7
|
| Accessions |
EDL27834 Q6NVG1 BC046276 BC068131 AAH68131 BC080829 AAH80829 NM_207206 NP_997089
|
| Function |
Displays acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates; converts lysophosphatidylethanolamine to phosphatidylethanolamine, 1-alkenyl-lysophatidylethanolamine to 1- alkenyl-phosphatidylethanolamine, lysophosphatidylglycerol and alkyl-lysophosphatidylcholine to phosphatidylglycerol and alkyl- phosphatidylcholine, respectively. In contrast, has no lysophosphatidylinositol, glycerol-3-phosphate, diacylglycerol or lysophosphatidic acid acyltransferase activity. Prefers long chain acyl-CoAs (C16, C18) as acyl donors (By similarity). Converts lysophosphatidylcholine to phosphatidycholine. {ECO:0000250, ECO:0000269|PubMed:18156367}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed with much higher level in brain. Expressed in erythroleukemic cells but not in reticulocytes. {ECO:0000269|PubMed:18156367, ECO:0000269|PubMed:18458083}.
|
| Top Pathways |
Ether lipid metabolism, Glycerophospholipid metabolism
|