| Gene Symbol |
MICU1
|
| Entrez Gene |
507899
|
| Alt Symbol |
CBARA1
|
| Species |
Bovine
|
| Gene Type |
protein-coding
|
| Description |
mitochondrial calcium uptake 1
|
| Other Description |
calcium binding atopy-related autoantigen 1|calcium uptake protein 1, mitochondrial|calcium-binding atopy-related autoantigen 1 homolog
|
| Swissprots |
Q0IIL1
|
| Accessions |
DAA14235 Q0IIL1 BC122590 AAI22591 XM_005226354 XP_005226411 XM_005226355 XP_005226412 XM_010820569 XP_010818871 XM_010820570 XP_010818872 NM_001075338 NP_001068806
|
| Function |
Key regulator of mitochondrial calcium uniporter (MCU) required to increase calcium uptake by MCU when cytoplasmic calcium is high. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, respectively. MICU1 acts as a stimulator of MCU that senses calcium level via its EF-hand domains: enhances MCU opening at high Ca(2+) concentration, allowing a rapid response of mitochondria to Ca(2+) signals generated in the cytoplasm. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Mitochondrion inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Mitochondrion intermembrane space {ECO:0000250}. Note=Localizes at the outer surface of the mitochondrion inner membrane. {ECO:0000250}.
|