| Gene Symbol | PACRG |
|---|---|
| Entrez Gene | 135138 |
| Alt Symbol | GLUP, HAK005771, PARK2CRG |
| Species | Human |
| Gene Type | protein-coding |
| Description | PARK2 co-regulated |
| Other Description | molecular chaperone/chaperonin-binding protein|parkin co-regulated gene protein|parkin coregulated gene protein |
| Swissprots | E1P5B5 Q8NHP5 Q6IMB8 Q9H1V9 Q8IZM1 Q96M98 |
| Accessions | EAW47563 EAW47564 EAW47565 EAW47566 Q96M98 AF546872 AAN37911 AK023829 AK057286 BAB71410 BC030642 AAH30642 BC044227 AAH44227 BK001670 DAA02134 HQ448626 ADQ33104 XM_005266824 XP_005266881 XM_005266825 XP_005266882 XM_005266826 XP_005266883 XM_006715344 XP_006715407 XM_006715345 XP_006715408 XM_011535456 XP_011533758 XM_011535457 XP_011533759 XM_011535458 XP_011533760 XM_011535459 XP_011533761 XM_011535460 XP_011533762 XM_011535461 XP_011533763 XM_011535462 XP_011533764 XM_011535463 XP_011533765 XM_011535464 XP_011533766 XM_011535465 XP_011533767 XM_011535466 XP_011533768 XM_011535467 XP_011533769 XM_011535468 XP_011533770 XM_011535469 XP_011533771 XM_011535470 XP_011533772 XM_011535471 XP_011533773 XM_011535472 XP_011533774 NM_001080378 NP_001073847 NM_001080379 NP_001073848 NM_152410 NP_689623 |
| Function | Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease. {ECO:0000269|PubMed:14532270}. |
| Tissue Specificity | Expressed in all immune tissues, spleen, lymph nodes, thymus, tonsils, leukocyte and bone marrow. Expressed also in heart, brain, skeletal muscle, kidney, lung and pancreas. Expressed in primary Schwann cells and very weakly by monocyte- derived macrophages the primary host cells of Mycobacterium leprae, the causative agent of leprosy. Component of Lewy bodies, intraneuronal inclusions found in the brain of Parkinson disease patients. {ECO:0000269|PubMed:14737177}. |
PACRG CRISPR/Cas9 KO Plasmid (h) - sc-408641 from Santa Cruz Biotechnology
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PACRG HDR Plasmid (h) - sc-408641-HDR from Santa Cruz Biotechnology
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PACRG Double Nickase Plasmid (h) - sc-408641-NIC from Santa Cruz Biotechnology
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PACRG Double Nickase Plasmid (h2) - sc-408641-NIC-2 from Santa Cruz Biotechnology
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PACRG CRISPR Activation Plasmid (h) - sc-408641-ACT from Santa Cruz Biotechnology
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PACRG CRISPR Activation Plasmid (h2) - sc-408641-ACT-2 from Santa Cruz Biotechnology
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PACRG Lentiviral Activation Particles (h) - sc-408641-LAC from Santa Cruz Biotechnology
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PACRG Lentiviral Activation Particles (h2) - sc-408641-LAC-2 from Santa Cruz Biotechnology
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PACRG siRNA (h) - sc-61277 from Santa Cruz Biotechnology
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PACRG shRNA Plasmid (h) - sc-61277-SH from Santa Cruz Biotechnology
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PACRG shRNA (h) Lentiviral Particles - sc-61277-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU149241 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16257 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16257 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04409 from Sigma-Aldrich
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PACRG siRNA (Human) - CRJ5160 from Cohesion Biosciences
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shRNA set against Human PACRG (NM_152410.2) - SHH369844 from Creative biogene
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shRNA set against Human PACRG(NM_152410.2) - SHR077186 from Creative biogene
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shRNA set against Human PACRG(NM_001080378.1) - SHR077334 from Creative biogene
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Human PACRG siRNA - orb275661 from Biorbyt
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PACRG shRNA Plasmid (Human) - CHJ5160 from Cohesion Biosciences
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PACRG miRNA 3'UTR clone - MiUTR1H-07456 from Creative biogene
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PACRG miRNA 3'UTR clone - MiUTR3H-09990 from Creative biogene
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PACRG miRNA 3'UTR clone - MiUTR3H-09991 from Creative biogene
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