| Gene Symbol |
Neu1
|
| Entrez Gene |
24591
|
| Alt Symbol |
-
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
neuraminidase 1
|
| Other Description |
N-acetyl-alpha-neuraminidase 1|lysosomal sialidase|sialidase 1 (lysosomal sialidase)|sialidase-1
|
| Swissprots |
Q99PW3
|
| Accessions |
CAE83976 EDL83468 EDL83469 Q99PW3 AB035722 BAB21443 BC100639 AAI00640 NM_031522 NP_113710
|
| Function |
Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage. {ECO:0000269|PubMed:11162581}.
|
| Subcellular Location |
Lysosome membrane {ECO:0000269|PubMed:11162581}; Peripheral membrane protein {ECO:0000269|PubMed:11162581}; Lumenal side {ECO:0000269|PubMed:11162581}. Lysosome lumen {ECO:0000269|PubMed:11162581}. Cell membrane {ECO:0000269|PubMed:11162581}. Cytoplasmic vesicle {ECO:0000269|PubMed:11162581}. Note=Localized not only on the inner side of the lysosomal membrane and in the lysosomal lumen, but also on the plasma membrane and in intracellular vesicles.
|
| Top Pathways |
Lysosome, Sphingolipid metabolism, Other glycan degradation
|