| Gene Symbol | Neu1 |
|---|---|
| Entrez Gene | 24591 |
| Alt Symbol | - |
| Species | Rat |
| Gene Type | protein-coding |
| Description | neuraminidase 1 |
| Other Description | N-acetyl-alpha-neuraminidase 1|lysosomal sialidase|sialidase 1 (lysosomal sialidase)|sialidase-1 |
| Swissprots | Q99PW3 |
| Accessions | CAE83976 EDL83468 EDL83469 Q99PW3 AB035722 BAB21443 BC100639 AAI00640 NM_031522 NP_113710 |
| Function | Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage. {ECO:0000269|PubMed:11162581}. |
| Subcellular Location | Lysosome membrane {ECO:0000269|PubMed:11162581}; Peripheral membrane protein {ECO:0000269|PubMed:11162581}; Lumenal side {ECO:0000269|PubMed:11162581}. Lysosome lumen {ECO:0000269|PubMed:11162581}. Cell membrane {ECO:0000269|PubMed:11162581}. Cytoplasmic vesicle {ECO:0000269|PubMed:11162581}. Note=Localized not only on the inner side of the lysosomal membrane and in the lysosomal lumen, but also on the plasma membrane and in intracellular vesicles. |
| Top Pathways | Lysosome, Sphingolipid metabolism, Other glycan degradation |