| Gene Symbol | PDHB |
|---|---|
| Entrez Gene | 5162 |
| Alt Symbol | PDHBD, PDHE1-B, PHE1B |
| Species | Human |
| Gene Type | protein-coding |
| Description | pyruvate dehydrogenase (lipoamide) beta |
| Other Description | pyruvate dehydrogenase E1 component subunit beta, mitochondrial|pyruvate dehydrogenase, E1 beta polypeptide |
| Swissprots | B2R7L0 Q9UFK3 Q9BQ27 Q6FH45 B4DDD7 P11177 |
| Accessions | BAA14123 EAW65371 EAW65372 EAW65373 P11177 AB209241 BAD92478 AK225569 AK225621 AK293153 BAG56698 AK311514 AK313022 BAG35857 AL117618 CAB56017 AL706543 AM392999 CAL37877 AM393278 CAL38156 BC000439 AAH00439 BC001924 AAH01924 BC004115 BM971427 CR541911 CAG46709 DA965753 DB039833 DQ891366 ABM82292 DQ894546 ABM85472 J03576 AAA88097 M19123 AAA60052 M19124 M34055 AAA60233 M34056 AAA60054 M34479 AAA36428 M54788 AAA60053 X57778 CAA40924 XM_011533828 XP_011532130 NM_000925 NP_000916 NM_001173468 NP_001166939 NR_033384 |
| Function | The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. {ECO:0000269|PubMed:17474719, ECO:0000269|PubMed:19081061}. |
| Subcellular Location | Mitochondrion matrix. |
| Top Pathways | Glycolysis / Gluconeogenesis, Citrate cycle (TCA cycle), Central carbon metabolism in cancer, Glucagon signaling pathway, Pyruvate metabolism |