| Gene Symbol |
EDS1
|
| Entrez Gene |
823964
|
| Alt Symbol |
ATEDS1, EDS1 PROTEIN, enhanced disease susceptibility 1
|
| Species |
Arabidopsis thaliana
|
| Gene Type |
protein-coding
|
| Description |
enhanced disease susceptibility 1 protein
|
| Other Description |
-
|
| Swissprots |
Q9SU72 B9DFM5
|
| Accessions |
ABR45989 ABR45993 ABR46002 AEE78366 AEE78367 CAB41130 Q9SU72 AK316830 BAH19542 AY046025 AAK76699 AY150423 AAN12884 NM_001035752 NP_001030829 NM_114678 NP_190392
|
| Function |
Positive regulator of basal resistance and of effector- triggered immunity specifically mediated by TIR-NB-LRR (TNL) resistance proteins. Disruption by bacterial effector of EDS1-TIR- NB-LRR resistance protein interactions constitutes the first step in resistance activation (PubMed:22158819). Acts redundantly with salicylic acid to regulate resistance gene-mediated signaling (PubMed:19578402). Triggers early plant defenses and hypersensitive response independently of PAD4, and then recruits PAD4 to potentiate plant defenses through the accumulation of salicylic acid (PubMed:11574472). Nuclear localization is essential for basal and TNL-conditioned immunity and for reprogramming defense gene expression, while cytoplasmic EDS1 is required to induce a complete immune response (PubMed:20617163). Heterodimerization with PAD4 and/or SGA101 is necessary for TNL- mediated effector-triggered immunity (PubMed:24331460). Contributes to nonhost resistance against E.amylovora (PubMed:22316300). Los
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:16040633, ECO:0000269|PubMed:22072959, ECO:0000269|PubMed:22158819}. Cytoplasm {ECO:0000269|PubMed:16040633, ECO:0000269|PubMed:22072959, ECO:0000269|PubMed:22158818, ECO:0000269|PubMed:22158819}. Microsome {ECO:0000269|PubMed:22158819}. Note=Found in both the nucleus and diffuse in the cytosol when associated with PAD4, in the nucleus and in punctate spots in the cytolasm when interacting with SRFR1, SNC1 or RPS4, only in the nucleus when associated with SAG101 and in the cytosol when it dimerizes. Found in the nucleus when interacting with VICTR and PAD4. Interacts with AvrRps4 and HopA1 effectors in microsomes. {ECO:0000269|PubMed:16040633, ECO:0000269|PubMed:22072959, ECO:0000269|PubMed:22158819, ECO:0000269|PubMed:23275581}.
|
| Top Pathways |
Plant-pathogen interaction
|
