Gene Symbol | Lrp2 |
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Entrez Gene | 14725 |
Alt Symbol | AI315343, AW536255, D230004K18Rik, Gp330, Megalin, b2b1625.2Clo |
Species | Mouse |
Gene Type | protein-coding |
Description | low density lipoprotein receptor-related protein 2 |
Other Description | LRP-2|glycoprotein 330|low-density lipoprotein receptor-related protein 2 |
Swissprots | Q3TL35 P70215 Q9JLB3 A2ARV4 |
Accessions | A2ARV4 AF197160 AAF61488 AK049346 BAE43341 AK084165 AK165434 AK166702 BAE38957 BC040788 Y08566 CAA69877 NM_001081088 NP_001074557 |
Function | Acts together with cubilin to mediate HDL endocytosis. {ECO:0000269|PubMed:10766831}. |
Subcellular Location | Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Membrane, coated pit {ECO:0000250}. |
Top Pathways | Hedgehog signaling pathway, Thyroid hormone synthesis |
megalin CRISPR/Cas9 KO Plasmid (m) - sc-420631 from Santa Cruz Biotechnology
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megalin HDR Plasmid (m) - sc-420631-HDR from Santa Cruz Biotechnology
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megalin Double Nickase Plasmid (m) - sc-420631-NIC from Santa Cruz Biotechnology
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megalin Double Nickase Plasmid (m2) - sc-420631-NIC-2 from Santa Cruz Biotechnology
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megalin CRISPR Activation Plasmid (m) - sc-420631-ACT from Santa Cruz Biotechnology
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megalin CRISPR Activation Plasmid (m2) - sc-420631-ACT-2 from Santa Cruz Biotechnology
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megalin Lentiviral Activation Particles (m) - sc-420631-LAC from Santa Cruz Biotechnology
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megalin Lentiviral Activation Particles (m2) - sc-420631-LAC-2 from Santa Cruz Biotechnology
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megalin siRNA (m) - sc-40104 from Santa Cruz Biotechnology
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megalin shRNA Plasmid (m) - sc-40104-SH from Santa Cruz Biotechnology
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megalin shRNA (m) Lentiviral Particles - sc-40104-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU203841 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN34948 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND34948 from Sigma-Aldrich
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LRP2 siRNA (Mouse) - CRM1638 from Cohesion Biosciences
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shRNA set against Mouse LRP2 (NM_001081088.1) - SHH334011 from Creative biogene
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shRNA set against Mouse Lrp2(NM_001081088.1) - SHH161201 from Creative biogene
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LRP2 shRNA Plasmid (Mouse) - CHM1638 from Cohesion Biosciences
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LRP2 miRNA 3'UTR clone - MiUTR1M-06747 from Creative biogene
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