Gene Symbol | GATA3 |
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Entrez Gene | 2625 |
Alt Symbol | HDR, HDRS |
Species | Human |
Gene Type | protein-coding |
Description | GATA binding protein 3 |
Other Description | GATA-binding factor 3|trans-acting T-cell-specific transcription factor GATA-3 |
Swissprots | Q5VWG8 Q5VWG7 P23771 Q96J16 |
Accessions | AAR32096 CAR95134 CAR95135 CBX53865 CBX53866 CDL93507 EAW86367 EAW86368 P23771 AI024501 AI686327 AK298213 BAG60483 AM392571 CAL37449 AM392688 CAL37566 BC003070 AAH03070 BC006793 AAH06793 BC006839 BG287052 BM152193 M69106 AAA35870 X55037 CAA38877 X55122 CAA38916 X58072 CAA41102 XM_005252442 XP_005252499 XM_005252443 XP_005252500 NM_001002295 NP_001002295 NM_002051 NP_002042 |
Function | Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. {ECO:0000269|PubMed:23824597}. |
Subcellular Location | Nucleus. |
Tissue Specificity | T-cells and endothelial cells. |
Top Pathways | Inflammatory bowel disease (IBD) |
GATA-3 CRISPR/Cas9 KO Plasmid (h) - sc-400134 from Santa Cruz Biotechnology
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GATA-3 HDR Plasmid (h) - sc-400134-HDR from Santa Cruz Biotechnology
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GATA-3 Double Nickase Plasmid (h) - sc-400134-NIC from Santa Cruz Biotechnology
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GATA-3 Double Nickase Plasmid (h2) - sc-400134-NIC-2 from Santa Cruz Biotechnology
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GATA-3 CRISPR Activation Plasmid (h) - sc-400134-ACT from Santa Cruz Biotechnology
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GATA-3 CRISPR Activation Plasmid (h2) - sc-400134-ACT-2 from Santa Cruz Biotechnology
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GATA-3 Lentiviral Activation Particles (h) - sc-400134-LAC from Santa Cruz Biotechnology
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GATA-3 Lentiviral Activation Particles (h2) - sc-400134-LAC-2 from Santa Cruz Biotechnology
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GATA-3 siRNA (h) - sc-29331 from Santa Cruz Biotechnology
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GATA-3 shRNA Plasmid (h) - sc-29331-SH from Santa Cruz Biotechnology
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GATA-3 shRNA (h) Lentiviral Particles - sc-29331-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU137721 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9148 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9148 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09035 from Sigma-Aldrich
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GATA3 siRNA (Human) - CRH1741 from Cohesion Biosciences
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GATA-3 RNAi - H00002625-R01 from Novus Biologicals
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GATA-3 RNAi - H00002625-R02 from Novus Biologicals
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GATA3 - MBS8239866 from MyBioSource
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GATA-3 CRISPR/Cas9 KO Plasmid (h2) - sc-400134-KO-2 from Santa Cruz Biotechnology
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GATA-3 HDR Plasmid (h2) - sc-400134-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human GATA3(NM_001002295.1) - SHH078167 from Creative biogene
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shRNA set against Human GATA3(NM_002051.2) - SHH078185 from Creative biogene
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Human GATA3 siRNA - orb262243 from Biorbyt
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GATA3 shRNA Plasmid (Human) - CHH1741 from Cohesion Biosciences
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