| Gene Symbol | Msh3 |
|---|---|
| Entrez Gene | 17686 |
| Alt Symbol | D13Em1, Rep-3, Rep3 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | mutS homolog 3 (E. coli) |
| Other Description | DNA mismatch repair protein Msh3|REP-1|protein repair-1|protein repair-3 |
| Swissprots | P13705 |
| Accessions | AAB60710 AAB60711 P13705 AK011426 AK040616 BAC30646 AK078467 BAE43365 AK083388 AK133907 AK161089 AK161430 BAE36392 BC025063 BC040784 AAH40784 BC150759 AAI50760 BQ571929 BY710130 CK022909 M24919 AAA40051 M80360 AAA40052 XM_006517541 XP_006517604 XM_006517542 XP_006517605 XM_006517543 XP_006517606 XM_006517545 XP_006517608 XM_006517547 XP_006517610 XM_011244626 XP_011242928 NM_010829 NP_034959 |
| Function | Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion- deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis (By similarity). {ECO:0000250}. |
| Top Pathways | Mismatch repair, Colorectal cancer |