| Gene Symbol | NXF1 |
|---|---|
| Entrez Gene | 10482 |
| Alt Symbol | MEX67, TAP |
| Species | Human |
| Gene Type | protein-coding |
| Description | nuclear RNA export factor 1 |
| Other Description | mRNA export factor TAP|tip associating protein|tip-associated protein|tip-associating protein |
| Swissprots | Q99799 B4E269 Q9UQL2 Q9UBU9 |
| Accessions | EAW74103 EAW74104 EAW74105 EAW74106 EAW74107 Q9UBU9 AB209915 BAD93152 AF112880 AAD39102 AF126246 AAD20016 AJ132712 CAA10753 AK027192 AK304082 BAG64989 AK304137 BAG65031 AK304743 BAG65502 AK307961 AK307998 AV750251 AW005685 BC004904 AAH04904 BC017421 BC028041 AAH28041 BM751313 CR749674 CAH18465 DB141140 DQ892931 ABM83857 DQ896180 ABM87179 U80073 AAB81111 NM_001081491 NP_001074960 NM_006362 NP_006353 |
| Function | Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export. {ECO:0000269|PubMed:18364396, ECO:0000269|PubMed:19165146, ECO:0000269|PubMed:9660949}. |
| Subcellular Location | Nucleus, nucleoplasm. Nucleus speckle. Cytoplasm. Note=Localized predominantly in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex. Shuttles between the nucleus and the cytoplasm. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. The association with the TREX complex seems to occur in regions surrounding nuclear speckles known as perispeckles. |
| Tissue Specificity | Expressed ubiquitously. |
| Top Pathways | RNA transport, mRNA surveillance pathway, Ribosome biogenesis in eukaryotes, Influenza A, Herpes simplex infection |