| Gene Symbol | NXF1 |
|---|---|
| Entrez Gene | 10482 |
| Alt Symbol | MEX67, TAP |
| Species | Human |
| Gene Type | protein-coding |
| Description | nuclear RNA export factor 1 |
| Other Description | mRNA export factor TAP|tip associating protein|tip-associated protein|tip-associating protein |
| Swissprots | Q99799 B4E269 Q9UQL2 Q9UBU9 |
| Accessions | EAW74103 EAW74104 EAW74105 EAW74106 EAW74107 Q9UBU9 AB209915 BAD93152 AF112880 AAD39102 AF126246 AAD20016 AJ132712 CAA10753 AK027192 AK304082 BAG64989 AK304137 BAG65031 AK304743 BAG65502 AK307961 AK307998 AV750251 AW005685 BC004904 AAH04904 BC017421 BC028041 AAH28041 BM751313 CR749674 CAH18465 DB141140 DQ892931 ABM83857 DQ896180 ABM87179 U80073 AAB81111 NM_001081491 NP_001074960 NM_006362 NP_006353 |
| Function | Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export. {ECO:0000269|PubMed:18364396, ECO:0000269|PubMed:19165146, ECO:0000269|PubMed:9660949}. |
| Subcellular Location | Nucleus, nucleoplasm. Nucleus speckle. Cytoplasm. Note=Localized predominantly in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex. Shuttles between the nucleus and the cytoplasm. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. The association with the TREX complex seems to occur in regions surrounding nuclear speckles known as perispeckles. |
| Tissue Specificity | Expressed ubiquitously. |
| Top Pathways | RNA transport, mRNA surveillance pathway, Ribosome biogenesis in eukaryotes, Influenza A, Herpes simplex infection |
TAP CRISPR/Cas9 KO Plasmid (h) - sc-402586 from Santa Cruz Biotechnology
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TAP HDR Plasmid (h) - sc-402586-HDR from Santa Cruz Biotechnology
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TAP Double Nickase Plasmid (h) - sc-402586-NIC from Santa Cruz Biotechnology
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TAP Double Nickase Plasmid (h2) - sc-402586-NIC-2 from Santa Cruz Biotechnology
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TAP CRISPR Activation Plasmid (h) - sc-402586-ACT from Santa Cruz Biotechnology
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TAP CRISPR Activation Plasmid (h2) - sc-402586-ACT-2 from Santa Cruz Biotechnology
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TAP Lentiviral Activation Particles (h) - sc-402586-LAC from Santa Cruz Biotechnology
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TAP Lentiviral Activation Particles (h2) - sc-402586-LAC-2 from Santa Cruz Biotechnology
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TAP siRNA (h) - sc-38142 from Santa Cruz Biotechnology
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TAP shRNA Plasmid (h) - sc-38142-SH from Santa Cruz Biotechnology
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TAP shRNA (h) Lentiviral Particles - sc-38142-V from Santa Cruz Biotechnology
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NXF1 RNAi - H00010482-R01 from Novus Biologicals
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MISSION® esiRNA - EHU010781 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15646 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15646 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02629 from Sigma-Aldrich
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NXF1 siRNA (Human) - CRH7119 from Cohesion Biosciences
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shRNA set against Human NXF1 (NM_006362.4) - SHH356704 from Creative biogene
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shRNA set against Human NXF1(NM_001081491.1) - SHR027826 from Creative biogene
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shRNA set against Human NXF1(NM_006362.4) - SHR028038 from Creative biogene
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shRNA set against Human NXF1(NM_001081491.1) - SHR028056 from Creative biogene
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Human NXF1 siRNA - orb267621 from Biorbyt
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NXF1 shRNA Plasmid (Human) - CHH7119 from Cohesion Biosciences
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NXF1 miRNA 3'UTR clone - MiUTR1H-07005 from Creative biogene
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NXF1 miRNA 3'UTR clone - MiUTR1H-07006 from Creative biogene
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