| Gene Symbol | ST3GAL1 |
|---|---|
| Entrez Gene | 6482 |
| Alt Symbol | Gal-NAc6S, SIAT4A, SIATFL, ST3GalA, ST3GalA.1, ST3GalIA, ST3GalIA,1, ST3O |
| Species | Human |
| Gene Type | protein-coding |
| Description | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 |
| Other Description | CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1|Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase|SIAT4-A|ST3GalI|alpha 2,3-ST 1|beta-galactoside alpha-2,3-sialyltransferase 1|sialyltransferase 4A (beta-galactosidase alpha-2,3-sialytransferase)|sialyltransferase 4A (beta-galactoside alpha-2,3-sialyltransferase)|sialyltransferase 4A (beta-galactoside alpha-2,3-sialytransferase) |
| Swissprots | O60677 Q9UN51 Q11201 |
| Accessions | CAS91688 EAW92172 EAW92173 EAW92174 Q11201 AF059321 AAC17874 AK093867 AK311319 AL709325 AL833743 BC018357 AAH18357 BC048803 BC063665 BX537506 BX648001 CN359425 DQ891156 ABM82082 DQ894335 ABM85261 L13972 AAC37574 L29555 AAA36612 XM_005251023 XP_005251080 XM_005251024 XP_005251081 XM_005251025 XP_005251082 XM_006716617 XP_006716680 XM_011517225 XP_011515527 XM_011517226 XP_011515528 NM_003033 NP_003024 NM_173344 NP_775479 |
| Function | It may be responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found on sugar chains O- linked to Thr or Ser and also as a terminal sequence on certain gangliosides. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values. |
| Subcellular Location | Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane- bound form in trans cisternae of Golgi. Secreted into the body fluid. |
| Tissue Specificity | Expressed in several tissues. Highest expression in lung, liver, skeletal muscle, kidney, pancreas, spleen and placenta. |
| Top Pathways | Mucin type O-Glycan biosynthesis, Glycosaminoglycan biosynthesis - keratan sulfate, Glycosphingolipid biosynthesis - globo series, Glycosphingolipid biosynthesis - ganglio series |