Gene Symbol | SLK |
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Entrez Gene | 9748 |
Alt Symbol | LOSK, STK2, bA16H23.1, se20-9 |
Species | Human |
Gene Type | protein-coding |
Description | STE20-like kinase |
Other Description | CTCL tumor antigen se20-9|Long Ste20-like Kinase|SNF1 (sucrose nonfermenting, yeast, homolog)-like kinase, SNF1 sucrose nonfermenting like kinase|SNF1 sucrose nonfermenting like kinase|STE20-like serine/threonine-protein kinase|STE20-related kinase|STE20-related serine/threonine-protein kinase|Ste20-related serine/threonine kinase|hSLK|serine/threonine-protein kinase 2 |
Swissprots | D3DRA1 O00211 Q86WW1 Q9NQL1 Q86WU7 Q92603 Q9NQL0 Q9H2G2 D3DRA0 Q6P1Z4 |
Accessions | CAV30708 CCQ43457 EAW49615 EAW49616 EAW49617 EAW49618 Q9H2G2 AB002804 BAA19655 AF273048 AAG34908 AK302855 BAG64041 AK307389 BC008697 BC036736 BC047762 AAH47762 BC047885 AAH47885 BC064804 AAH64804 BC111565 AAI11566 BX648375 D86959 BAA13195 EF139853 XM_011540401 XP_011538703 NM_001304743 NP_001291672 NM_014720 NP_055535 |
Function | Mediates apoptosis and actin stress fiber dissolution. {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000250}. |
Tissue Specificity | Ubiquitously expressed. Highest expression is found in heart and in skeletal muscle. {ECO:0000269|PubMed:10699464}. |
Top Pathways | Oocyte meiosis |
SLK CRISPR/Cas9 KO Plasmid (h) - sc-406490 from Santa Cruz Biotechnology
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SLK HDR Plasmid (h) - sc-406490-HDR from Santa Cruz Biotechnology
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SLK Double Nickase Plasmid (h) - sc-406490-NIC from Santa Cruz Biotechnology
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SLK Double Nickase Plasmid (h2) - sc-406490-NIC-2 from Santa Cruz Biotechnology
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SLK CRISPR Activation Plasmid (h) - sc-406490-ACT from Santa Cruz Biotechnology
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SLK CRISPR Activation Plasmid (h2) - sc-406490-ACT-2 from Santa Cruz Biotechnology
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SLK Lentiviral Activation Particles (h) - sc-406490-LAC from Santa Cruz Biotechnology
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SLK Lentiviral Activation Particles (h2) - sc-406490-LAC-2 from Santa Cruz Biotechnology
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SLK siRNA (h) - sc-76514 from Santa Cruz Biotechnology
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SLK shRNA Plasmid (h) - sc-76514-SH from Santa Cruz Biotechnology
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SLK shRNA (h) Lentiviral Particles - sc-76514-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU123281 from Sigma-Aldrich
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MISSION® siRNA - SIHK2090 from Sigma-Aldrich
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MISSION® siRNA - SIHK2089 from Sigma-Aldrich
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MISSION® siRNA - SIHK2088 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19735 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19735 from Sigma-Aldrich
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SLK siRNA (Human) - CRH6515 from Cohesion Biosciences
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SLK RNAi - H00009748-R03 from Novus Biologicals
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SLK - MBS8231996 from MyBioSource
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SLK CRISPR/Cas9 KO Plasmid (h2) - sc-406490-KO-2 from Santa Cruz Biotechnology
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SLK HDR Plasmid (h2) - sc-406490-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human SLK (NM_014720.2) - SHH412784 from Creative biogene
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shRNA set against Human SLK(NM_014720.2) - SHL014734 from Creative biogene
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SLK shRNA Plasmid (Human) - CHH6515 from Cohesion Biosciences
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