| Gene Symbol | Tspan12 |
|---|---|
| Entrez Gene | 269831 |
| Alt Symbol | 9030619E17, AI426782, AI663988, AW111457, Tm4sf12 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | tetraspanin 12 |
| Other Description | tetraspanin-12|transmembrane 4 superfamily member 12|tspan-12 |
| Swissprots | Q8BKT6 Q6P1C3 Q8BZU1 |
| Accessions | EDL13854 EDL13855 EDL13856 EDL13857 Q8BKT6 AK033554 BAC28354 AK050737 BAC34399 AK199414 BC065152 AAH65152 BC068240 AAH68240 XM_006505090 XP_006505153 XM_006505091 XP_006505154 XM_011241063 XP_011239365 NM_173007 NP_766595 |
| Function | Regulator of cell surface receptor signal transduction. Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity (By similarity). Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta- catenin (CTNNB1). {ECO:0000250, ECO:0000269|PubMed:19837033}. |
| Subcellular Location | Cell membrane {ECO:0000305|PubMed:19837033}; Multi-pass membrane protein {ECO:0000305|PubMed:19837033}. |
| Tissue Specificity | Expressed in the neonatal retinal vasculature but not other retinal tissues. Also detected in the neonatal meningeal vasculature and in nonvascular cell types, such as the smooth muscle cells in the neonatal intestine. {ECO:0000269|PubMed:19837033}. |