RARA

Gene Symbol	RARA
Entrez Gene	5914
Alt Symbol	NR1B1, RAR
Species	Human
Gene Type	protein-coding
Description	retinoic acid receptor, alpha
Other Description	RAR-alpha|nuclear receptor subfamily 1 group B member 1|nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form|retinoic acid nuclear receptor alpha variant 1|retinoic acid nuclear receptor alpha variant 2|retinoic acid receptor alpha|retinoic acid receptor, alpha polypeptide
Swissprots	P78456 B8Y636 Q9NQS0 P10276
Accessions	AAD05222 AAD13888 AAF87249 CAA39533 CAM91168 EAW60652 EAW60653 EAW60654 EAW60655 EAW60656 EAW60657 EAW60658 P10276 AK098172 BAG53585 AK130192 AK292205 BAF84894 AK303868 BAG64806 AK312564 BAG35459 AL522713 AL834159 CAH56277 BC008727 AAH08727 BC071733 AAH71733 BG394590 BM838347 BM992549 BY799725 CB105313 CR457438 CAG33719 DA061829 DA541711 DQ893531 ABM84457 DQ893744 ABM84670 FJ487576 ACK86665 HQ692826 ADZ17337 HQ692827 ADZ17338 S50916 AAB19602 X06538 CAA29787 X06614 CAA29829 X58685 CAA41532 XM_005257552 XP_005257609 XM_005257553 XP_005257610 XM_005257554 XP_005257611 XM_011525095 XP_011523397 XM_011525096 XP_011523398 NM_000964 NP_000955 NM_001024809 NP_001019980 NM_001145301 NP_001138773 NM_001145302 NP_001138774 NM_001033603
Function	Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meio
Subcellular Location	Nucleus. Cytoplasm. Note=Nuclear localization depends on ligand binding, phosphorylation and sumoylation. Transloaction to the nucleus in the absence of ligand is dependent on activation of PKC and the downstream MAPK phosphorylation.
Top Pathways	Acute myeloid leukemia, Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

RARα CRISPR/Cas9 KO Plasmid (h) - sc-400529 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

RARα HDR Plasmid (h) - sc-400529-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

RARα Double Nickase Plasmid (h) - sc-400529-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

RARα Double Nickase Plasmid (h2) - sc-400529-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

RARα CRISPR Activation Plasmid (h) - sc-400529-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

RARα CRISPR Activation Plasmid (h2) - sc-400529-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

RARα Lentiviral Activation Particles (h) - sc-400529-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

RARα Lentiviral Activation Particles (h2) - sc-400529-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

RARα siRNA (h) - sc-29465 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

RARα shRNA Plasmid (h) - sc-29465-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

RARα shRNA (h) Lentiviral Particles - sc-29465-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

RAR alpha/NR1B1 RNAi - H00005914-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

RAR alpha/NR1B1 RNAi - H00005914-R03 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

RAR alpha/NR1B1 RNAi - H00005914-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU064271 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1853 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1853 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

RARA siRNA (Human) - CRH4000 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

RARA - MBS8233281 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human RARA(NM_001145302.2) - SHR165228 from Creative biogene Category siRNA Species Reactivities Human

RARA shRNA Plasmid (Human) - CHH4000 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

RARA miRNA 3'UTR clone - MiUTR1H-08632 from Creative biogene Species Reactivities Human

RARA miRNA 3'UTR clone - MiUTR3H-02029 from Creative biogene Species Reactivities Human

RARA miRNA 3'UTR clone - MiUTR3H-02030 from Creative biogene Species Reactivities Human

RARA miRNA 3'UTR clone - MiUTR3H-02031 from Creative biogene Species Reactivities Human

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