Gene Symbol | KLK1 |
---|---|
Entrez Gene | 3816 |
Alt Symbol | KLKR, Klk6, hK1 |
Species | Human |
Gene Type | protein-coding |
Description | kallikrein 1 |
Other Description | glandular kallikrein 1|kallikrein 1, renal/pancreas/salivary|kallikrein serine protease 1|kallikrein-1|kidney/pancreas/salivary gland kallikrein|tissue kallikrein |
Swissprots | Q9UMJ1 Q66US9 Q9UD19 P06870 Q8TCV8 Q9NQU4 Q86U61 Q9BS53 |
Accessions | AAA36135 AAA59455 AAF86333 AAG33353 AAM11874 EAW71912 EAW71913 EAW71914 P06870 AK293363 BAH11493 AY429508 AAR10467 AY703451 AAU12569 BC005313 AAH05313 BP323011 BT007253 AAP35917 CA772631 DQ893072 ABM83998 DQ896328 ABM87327 M12706 AAA59201 M25629 AAA36136 S77952 AAB34120 X13561 CAA31912 XM_011526942 XP_011525244 NM_002257 NP_002248 |
Function | Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. |
Tissue Specificity | Isoform 2 is expressed in pancreas, salivary glands, kidney, colon, prostate gland, testis, spleen and the colon adenocarcinoma cell line T84. {ECO:0000269|PubMed:7749372}. |
Top Pathways | Endocrine and other factor-regulated calcium reabsorption |