| Gene Symbol |
GPER1
|
| Entrez Gene |
2852
|
| Alt Symbol |
CEPR, CMKRL2, DRY12, FEG-1, GPCR-Br, GPER, GPR30, LERGU, LERGU2, LyGPR, mER
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
G protein-coupled estrogen receptor 1
|
| Other Description |
G protein-coupled receptor 30|G-protein coupled estrogen receptor 1|IL8-related receptor DRY12|chemoattractant receptor-like 2|chemokine receptor-like 2|constitutively expressed peptide-like receptor|flow-induced endothelial G-protein coupled receptor 1|heptahelix receptor|leucine rich protein in GPR30 3'UTR|lymphocyte-derived G-protein coupled receptor|membrane estrogen receptor
|
| Swissprots |
O00143 B5BUJ1 O43494 A8K6C5 Q99981 Q99527 Q96F42 Q13631 Q6FHL1
|
| Accessions |
AAC51173 AAC52027 EAL23938 EAW87194 EAW87195 Q99527 AB451427 BAG70241 AF015257 AAC51904 AK289588 BAF82277 AY265807 AAP40320 AY265808 AAP40321 AY265809 AAP40322 BC011634 AAH11634 BC067849 BC082766 AAH82766 BM672716 CR541655 CAG46456 CR541741 CAG46541 DA014990 DC381205 DQ891902 ABM82828 DQ895088 ABM86014 U58828 AAB02736 U63917 AAB88017 X98510 CAA67133 Y08162 CAA69354 NM_001039966 NP_001035055 NM_001098201 NP_001091671 NM_001505 NP_001496 NM_001031682
|
| Function |
G-protein coupled estrogen receptor that binds to 17- beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine, reproductive, immune and central nervous systems. Has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner. Regulates arterial blood pressure by stimulating vasodilation and reducing vascular smooth muscle and microvascular endothelial cell proliferation. Plays a role in blood glucose homeostasis contributing to the insulin secretion response by pancreatic beta cells. Triggers mitoc
|
| Subcellular Location |
Nucleus. Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Cell membrane; Multi- pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Early endosome. Recycling endosome. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus, trans-Golgi network. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, axon {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Mitochondrion membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Colocalized with BSN to the active zone of presynaptic density. Colocalized with DLG4/PSD95 and neurabin-2 PPP1R9B in neuronal synaptosomes (By similarity). Endocytosed in a agonis
|
| Tissue Specificity |
Expressed in placenta, endothelial and epithelial cells, non laboring and laboring term myometrium, fibroblasts and cancer-associated fibroblasts (CAF), prostate cancer cells and invasive adenocarcinoma (at protein level). Ubiquitously expressed, but is most abundant in placenta. In brain regions, expressed as a 2.8 kb transcript in basal forebrain, frontal cortex, thalamus, hippocampus, caudate and putamen. {ECO:0000269|PubMed:20203690, ECO:0000269|PubMed:20551055, ECO:0000269|PubMed:21149639, ECO:0000269|PubMed:21354433, ECO:0000269|PubMed:21427217, ECO:0000269|PubMed:23285008}.
|
| Top Pathways |
Estrogen signaling pathway
|
