Gene Symbol | ARL13B |
---|---|
Entrez Gene | 200894 |
Alt Symbol | ARL2L1, JBTS8 |
Species | Human |
Gene Type | protein-coding |
Description | ADP-ribosylation factor-like 13B |
Other Description | ADP-ribosylation factor-like 2-like 1|ADP-ribosylation factor-like protein 13B|ARL2-like protein 1 |
Swissprots | G3V1S8 Q8TCL5 Q3SXY8 Q504W8 D3DN29 |
Accessions | CCO13680 EAW79897 EAW79898 EAW79899 EAW79900 EAW79901 Q3SXY8 AA775026 AK296994 BAG59533 AK299284 BAG61300 AL713789 CAD28544 BC015439 BC031093 BC062993 BC073842 BC094725 AAH94725 BC104033 BC104034 BC104035 AAI04036 BC104036 AAI04037 BI821381 CR936753 CR936756 CR936763 EU832148 ACE87498 EU832241 ACE86811 EU832840 ACE87851 GQ129241 ACT64375 XM_006713531 XP_006713594 XM_006713532 XP_006713595 XM_011512532 XP_011510834 XM_011512533 XP_011510835 XM_011512534 XP_011510836 XM_011512535 XP_011510837 XM_011512536 XP_011510838 NM_001174150 NP_001167621 NM_001174151 NP_001167622 NM_144996 NP_659433 NM_182896 NP_878899 NR_033427 |
Function | Cilium-specific protein required to control the microtubule-based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic interneurons in the developing cerebral cortex. May regulate endocytic recycling traffic; however, additional evidences are required to confirm these data. {ECO:0000269|PubMed:23150559}. |
Subcellular Location | Cell projection, cilium membrane {ECO:0000269|PubMed:18554500, ECO:0000269|PubMed:24120134}; Lipid- anchor {ECO:0000269|PubMed:18554500, ECO:0000269|PubMed:24120134}. Note=Associates to the cilium membrane via palmitoylation. Localizes to proximal ciliary membranes, to an inversin-like subciliary membrane compartment, excluding the transition zone. |
ARL13B CRISPR/Cas9 KO Plasmid (h) - sc-417325 from Santa Cruz Biotechnology
|
||||||||
ARL13B HDR Plasmid (h) - sc-417325-HDR from Santa Cruz Biotechnology
|
||||||||
ARL13B Double Nickase Plasmid (h) - sc-417325-NIC from Santa Cruz Biotechnology
|
||||||||
ARL13B Double Nickase Plasmid (h2) - sc-417325-NIC-2 from Santa Cruz Biotechnology
|
||||||||
ARL13B CRISPR Activation Plasmid (h) - sc-417325-ACT from Santa Cruz Biotechnology
|
||||||||
ARL13B CRISPR Activation Plasmid (h2) - sc-417325-ACT-2 from Santa Cruz Biotechnology
|
||||||||
ARL13B Lentiviral Activation Particles (h) - sc-417325-LAC from Santa Cruz Biotechnology
|
||||||||
ARL13B Lentiviral Activation Particles (h2) - sc-417325-LAC-2 from Santa Cruz Biotechnology
|
||||||||
ARL13B siRNA (h) - sc-78165 from Santa Cruz Biotechnology
|
||||||||
ARL13B shRNA Plasmid (h) - sc-78165-SH from Santa Cruz Biotechnology
|
||||||||
ARL13B shRNA (h) Lentiviral Particles - sc-78165-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU125871 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN3481 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3481 from Sigma-Aldrich
|
||||||||
ARL13B siRNA (Human) - CRJ6265 from Cohesion Biosciences
|
||||||||
ARL13B - MBS8233898 from MyBioSource
|
||||||||
shRNA set against Human ARL13B (NM_182896.2) - SHH240118 from Creative biogene
|
||||||||
Human ARL13B siRNA - orb276766 from Biorbyt
|
||||||||
ARL13B shRNA Plasmid (Human) - CHJ6265 from Cohesion Biosciences
|
||||||||
ARL13B miRNA 3'UTR clone - MiUTR4H-TG00505 from Creative biogene
|