| Gene Symbol | WNT6 |
|---|---|
| Entrez Gene | 7475 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | wingless-type MMTV integration site family, member 6 |
| Other Description | protein Wnt-6 |
| Swissprots | Q9H1J6 Q9Y6F9 Q9H238 |
| Accessions | AAD41674 AAG45154 AAY24174 CAI38647 EAW70658 Q9Y6F9 AB059570 BAB55603 AK075522 BAC11668 AY009401 AAG38661 BC004329 AAH04329 BT007456 AAP36124 CB960823 DQ890770 ABM81696 XM_011511782 XP_011510084 NM_006522 NP_006513 |
| Function | Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Together with CAV1 may promote chemoresistance of gastric cancer cells to DNA-damaging anthracycline drugs through the activation of the canonical Wnt receptor signaling pathway. {ECO:0000269|PubMed:22370641}. |
| Subcellular Location | Secreted, extracellular space, extracellular matrix. |
| Tissue Specificity | Expressed in gastric cancer cell lines and gastric cancer tissues (at protein level). Detected in the apical gland region of the gastric foveolar epithelium (at protein level). {ECO:0000269|PubMed:22370641}. |
| Top Pathways | Proteoglycans in cancer, Wnt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Hippo signaling pathway, HTLV-I infection |