Gene Symbol | WNT6 |
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Entrez Gene | 7475 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | wingless-type MMTV integration site family, member 6 |
Other Description | protein Wnt-6 |
Swissprots | Q9H1J6 Q9Y6F9 Q9H238 |
Accessions | AAD41674 AAG45154 AAY24174 CAI38647 EAW70658 Q9Y6F9 AB059570 BAB55603 AK075522 BAC11668 AY009401 AAG38661 BC004329 AAH04329 BT007456 AAP36124 CB960823 DQ890770 ABM81696 XM_011511782 XP_011510084 NM_006522 NP_006513 |
Function | Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Together with CAV1 may promote chemoresistance of gastric cancer cells to DNA-damaging anthracycline drugs through the activation of the canonical Wnt receptor signaling pathway. {ECO:0000269|PubMed:22370641}. |
Subcellular Location | Secreted, extracellular space, extracellular matrix. |
Tissue Specificity | Expressed in gastric cancer cell lines and gastric cancer tissues (at protein level). Detected in the apical gland region of the gastric foveolar epithelium (at protein level). {ECO:0000269|PubMed:22370641}. |
Top Pathways | Proteoglycans in cancer, Wnt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Hippo signaling pathway, HTLV-I infection |
Wnt-6 CRISPR/Cas9 KO Plasmid (h) - sc-407737 from Santa Cruz Biotechnology
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Wnt-6 HDR Plasmid (h) - sc-407737-HDR from Santa Cruz Biotechnology
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Wnt-6 Double Nickase Plasmid (h) - sc-407737-NIC from Santa Cruz Biotechnology
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Wnt-6 Double Nickase Plasmid (h2) - sc-407737-NIC-2 from Santa Cruz Biotechnology
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Wnt-6 CRISPR Activation Plasmid (h) - sc-407737-ACT from Santa Cruz Biotechnology
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Wnt-6 CRISPR Activation Plasmid (h2) - sc-407737-ACT-2 from Santa Cruz Biotechnology
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Wnt-6 Lentiviral Activation Particles (h) - sc-407737-LAC from Santa Cruz Biotechnology
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Wnt-6 Lentiviral Activation Particles (h2) - sc-407737-LAC-2 from Santa Cruz Biotechnology
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Wnt-6 siRNA (h) - sc-94607 from Santa Cruz Biotechnology
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Wnt-6 shRNA Plasmid (h) - sc-94607-SH from Santa Cruz Biotechnology
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Wnt-6 shRNA (h) Lentiviral Particles - sc-94607-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN22922 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22922 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12081 from Sigma-Aldrich
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WNT6 siRNA (Human) - CRH5114 from Cohesion Biosciences
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WNT6 - MBS8231357 from MyBioSource
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shRNA set against Human WNT6 (NM_006522.3) - SHH447340 from Creative biogene
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shRNA set against Human WNT6(NM_006522.3) - SHL136218 from Creative biogene
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Human WNT6 siRNA - orb265616 from Biorbyt
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WNT6 shRNA Plasmid (Human) - CHH5114 from Cohesion Biosciences
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WNT6 miRNA 3'UTR clone - MiUTR1H-11283 from Creative biogene
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