| Gene Symbol |
APEX2
|
| Entrez Gene |
27301
|
| Alt Symbol |
APE2, APEXL2, XTH2, ZGRF2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
APEX nuclease (apurinic/apyrimidinic endonuclease) 2
|
| Other Description |
AP endonuclease 2|AP endonuclease XTH2|DNA-(apurinic or apyrimidinic site) lyase 2|apurinic/apyrimidinic endonuclease-like 2|zinc finger, GRF-type containing 2
|
| Swissprots |
Q9Y5X7 Q9UBZ4
|
| Accessions |
AAW56941 ADP90654 ADP90655 ADP90656 ADP90657 ADP90658 ADP90659 ADP90660 ADP90661 ADP90662 ADP90663 ADP90664 ADP90665 ADP90666 ADP90667 ADP90668 ADP90669 ADP90670 ADP90671 ADP90672 ADP90673 ADP90674 ADP90675 ADP90676 ADP90677 ADP90678 ADP90679 ADP90680 ADP90681 ADP90682 ADP90683 ADP90684 ADP90685 ADP90686 ADP90687 ADP90688 ADP90689 ADP90690 ADP90691 ADP90692 ADP90693 CCQ43440 EAW93208 EAW93209 EAW93210 Q9UBZ4 AB021260 BAA78422 AB049211 BAB13764 AF119046 AAD43041 AJ011311 CAB45242 AK301555 BAG63051 AK316186 BAH14557 BC002959 AAH02959 BI837686 BM795632 BP363514 DQ893669 ABM84595 DQ895556 ABM86482 NM_001271748 NP_001258677 NM_014481 NP_055296
|
| Function |
Function as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Displays also double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities. Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially. Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents. In the nucleus functions in the PCNA-dependent BER pathway. Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes. Required for proper cell cycle progression during proliferation of peri
|
| Subcellular Location |
Nucleus. Cytoplasm. Mitochondrion {ECO:0000305}. Note=Together with PCNA, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents.
|
| Tissue Specificity |
Highly expressed in brain and kidney. Weakly expressed in the fetal brain. {ECO:0000269|PubMed:11376153}.
|
| Top Pathways |
Base excision repair
|
![Western Blot: APEX2 Overexpression Lysate (Adult Normal) [NBP2-07324] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for APEX2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8236_APEX2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-07324-img0001.jpg)