VSX1
| Gene Symbol | VSX1 |
|---|---|
| Entrez Gene | 30813 |
| Alt Symbol | CAASDS, KTCN, KTCN1, PPCD, PPCD1, PPD, RINX |
| Species | Human |
| Gene Type | protein-coding |
| Description | visual system homeobox 1 |
| Other Description | homeodomain protein RINX|retinal inner nuclear layer homeobox protein|transcription factor VSX1 |
| Swissprots | Q0GM61 B9EGJ4 Q9NU27 Q9HCU3 Q0GM63 Q9NZR4 Q0GM62 D1MF28 Q0GM65 Q5TF41 Q0GM64 Q0GM60 Q5TF40 |
| Accessions | ACZ01961 ADC97915 EAX10104 EAX10105 Q9NZR4 AF176797 AAF37425 AF251033 AAF99656 AF251034 AAF99657 BC126228 AAI26229 BC136497 AAI36498 BM680858 BM712470 DQ854807 ABI23973 DQ854808 ABI23974 DQ854809 ABI23975 DQ854810 ABI23976 DQ854811 ABI23977 DQ854812 ABI23978 NM_001256271 NP_001243200 NM_001256272 NP_001243201 NM_014588 NP_055403 NM_199425 NP_955457 NR_045948 NR_045951 |
| Function | Binds to the 37-bp core of the locus control region (LCR) of the red/green visual pigment gene cluster. May regulate the activity of the LCR and the cone opsin genes at earlier stages of development. |
| Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108}. |
| Tissue Specificity | In the adult eye, expressed in lens, iris, ciliary body, choroid, optical nerve head and, most strongly, in retina, but not expressed in sclera and cornea. According to PubMed 11978762, expressed in adult retina but not in lens and cornea. Within adult retina, found exclusively in the inner nuclear layer. Isoform 1, isoform 2, isoform 3 and isoform 4 expressed in adult retina, but not in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle. Not expressed in thymus and spleen. Expressed in embryonic craniofacial tissue. Expressed in fetal (week 14) retina. Strongly expressed in neonatal retina (day 0), weakly in neonatal lens (day 0), choroid (day 0) and cornea (day 0, 4; month 9). {ECO:0000269|PubMed:10673340, ECO:0000269|PubMed:10903837, ECO:0000269|PubMed:11978762, ECO:0000269|PubMed:18253095}. |
VSX1 CRISPR/Cas9 KO Plasmid (h) - sc-405400 from Santa Cruz Biotechnology
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VSX1 HDR Plasmid (h) - sc-405400-HDR from Santa Cruz Biotechnology
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VSX1 Double Nickase Plasmid (h) - sc-405400-NIC from Santa Cruz Biotechnology
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VSX1 Double Nickase Plasmid (h2) - sc-405400-NIC-2 from Santa Cruz Biotechnology
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VSX1 CRISPR Activation Plasmid (h) - sc-405400-ACT from Santa Cruz Biotechnology
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VSX1 CRISPR Activation Plasmid (h2) - sc-405400-ACT-2 from Santa Cruz Biotechnology
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VSX1 Lentiviral Activation Particles (h) - sc-405400-LAC from Santa Cruz Biotechnology
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VSX1 Lentiviral Activation Particles (h2) - sc-405400-LAC-2 from Santa Cruz Biotechnology
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VSX1 siRNA (h) - sc-38806 from Santa Cruz Biotechnology
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VSX1 shRNA Plasmid (h) - sc-38806-SH from Santa Cruz Biotechnology
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VSX1 shRNA (h) Lentiviral Particles - sc-38806-V from Santa Cruz Biotechnology
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VSX1 RNAi - H00030813-R01 from Novus Biologicals
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VSX1 RNAi - H00030813-R02 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN22749 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22749 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07216 from Sigma-Aldrich
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VSX1 siRNA (Human) - CRH9340 from Cohesion Biosciences
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VSX1 - MBS8204465 from MyBioSource
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shRNA set against Human Vsx1 (NM_199425.2) - SHH445308 from Creative biogene
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Human VSX1 siRNA - orb269842 from Biorbyt
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VSX1 shRNA Plasmid (Human) - CHH9340 from Cohesion Biosciences
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