Gene Symbol | KEL |
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Entrez Gene | 3792 |
Alt Symbol | CD238, ECE3 |
Species | Human |
Gene Type | protein-coding |
Description | Kell blood group, metallo-endopeptidase |
Other Description | kell blood group antigen|kell blood group glycoprotein |
Swissprots | Q99885 Q96RS8 B2RBV4 P23276 |
Accessions | AAB33459 AAB47018 AAK69488 AAO38053 ABI75043 ABI96895 ABN11470 ABN11471 ABN11472 AER09781 AER24531 AER24532 AER57831 AGW99988 AGZ61918 AGZ61919 AHI18579 AHI18580 AHI18581 AHI18582 AHI18583 AHW82868 CAJ30267 CAJ30268 CAJ30269 CAJ30270 CAJ30271 CAJ30272 CAJ30273 CAJ30274 CAJ30275 CAJ30276 CAJ30277 CAJ30278 CAJ30279 CAJ30280 CAJ30281 CAJ30282 CAJ75457 CAJ75458 CAJ75459 CAL48386 CAP18775 CAR63890 CAR63912 CDG15322 CDH92903 CDH92904 CDH93728 CEJ95651 EAW51891 EAW51892 EAW51893 P23276 AK314831 BAG37351 AW294875 BC003135 AAH03135 BC050639 AAH50639 DQ896776 ABM87775 EU176416 ABW03867 FN998902 CBS91665 HE572750 CCC42286 KC922434 M64934 AAA03192 S76770 AAB33389 XM_005249993 XP_005250050 XM_005249994 XP_005250051 XM_005276988 XP_005277045 XM_005276989 XP_005277046 NM_000420 NP_000411 |
Function | Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3. {ECO:0000269|PubMed:10438732}. |
Subcellular Location | Cell membrane; Single-pass type II membrane protein. Note=Spans the erythrocyte membrane, and is attached to the underlying cytoskeleton. |
Tissue Specificity | Expressed at high levels in erythrocytes and testis (in Sertoli cells), and, at lower levels, in skeletal muscle, tonsils (in follicular dendritic cells), lymph node, spleen and appendix (at protein level). Also expressed in many adult and fetal nonerythroid tissues, including brain, spleen, lymph nodes and bone marrow. {ECO:0000269|PubMed:10891471, ECO:0000269|PubMed:11336649}. |
Kell CRISPR/Cas9 KO Plasmid (h) - sc-410850 from Santa Cruz Biotechnology
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Kell HDR Plasmid (h) - sc-410850-HDR from Santa Cruz Biotechnology
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Kell Double Nickase Plasmid (h) - sc-410850-NIC from Santa Cruz Biotechnology
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Kell Double Nickase Plasmid (h2) - sc-410850-NIC-2 from Santa Cruz Biotechnology
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Kell CRISPR Activation Plasmid (h) - sc-410850-ACT from Santa Cruz Biotechnology
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Kell CRISPR Activation Plasmid (h2) - sc-410850-ACT-2 from Santa Cruz Biotechnology
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Kell Lentiviral Activation Particles (h) - sc-410850-LAC from Santa Cruz Biotechnology
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Kell Lentiviral Activation Particles (h2) - sc-410850-LAC-2 from Santa Cruz Biotechnology
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Kell siRNA (h) - sc-72103 from Santa Cruz Biotechnology
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Kell shRNA Plasmid (h) - sc-72103-SH from Santa Cruz Biotechnology
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Kell shRNA (h) Lentiviral Particles - sc-72103-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU033181 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1707 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1707 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00167 from Sigma-Aldrich
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KEL siRNA (Human) - CRH2565 from Cohesion Biosciences
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Kell RNAi - H00003792-R01 from Novus Biologicals
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shRNA set against Human KEL (NM_000420.2) - SHH324335 from Creative biogene
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shRNA set against Human KEL(NM_000420.2) - SHL194034 from Creative biogene
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Human KEL siRNA - orb263067 from Biorbyt
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KEL shRNA Plasmid (Human) - CHH2565 from Cohesion Biosciences
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KEL miRNA 3'UTR clone - MiUTR1H-05190 from Creative biogene
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