| Gene Symbol | Nlgn1 |
|---|---|
| Entrez Gene | 192167 |
| Alt Symbol | 6330415N05Rik, BB179718, NL1, Nlg1, mKIAA1070 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | neuroligin 1 |
| Other Description | neuroligin-1 |
| Swissprots | Q99K10 |
| Accessions | Q99K10 AK078063 AK083116 AK122433 BAC65715 AK138209 BAE23583 AK158508 AK158813 BAE34679 AK162384 BAE36885 BC005523 AAH05523 BC098461 AAH98461 XM_006535415 XP_006535478 XM_006535416 XP_006535479 XM_006535418 XP_006535481 XM_006535419 XP_006535482 XM_006535420 XP_006535483 XM_006535421 XP_006535484 XM_006535422 XP_006535485 XM_006535423 XP_006535486 XM_006535424 XP_006535487 XM_006535425 XP_006535488 XM_006535426 XP_006535489 XM_011249667 XP_011247969 XM_011249668 XP_011247970 NM_001163387 NP_001156859 NM_138666 NP_619607 |
| Function | Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep (PubMed:23716671). {ECO:0000269|PubMed:10892652, ECO:0000269|PubMed:15620359, ECO:0000269|PubMed:16982420, ECO:0000269|PubMed:23716671}. |
| Subcellular Location | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Note=Enriched in synaptic plasma membranes and clustered in synaptic clefts and postsynaptic densities. Detected at dendritic spines. Colocalized with DLG4/PSD-95 and GRIN1/NMDAR1 (By similarity). {ECO:0000250}. |
| Tissue Specificity | Brain and arteries (at protein level). Expressed in olfactory bulb. Detected in brain. {ECO:0000269|PubMed:11329178, ECO:0000269|PubMed:16982420, ECO:0000269|PubMed:18434543, ECO:0000269|PubMed:19926856}. |
| Top Pathways | Cell adhesion molecules (CAMs) |