| Gene Symbol |
HTR3C
|
| Entrez Gene |
170572
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
5-hydroxytryptamine (serotonin) receptor 3C, ionotropic
|
| Other Description |
5-HT3-C|5-HT3C|5-hydroxytryptamine (serotonin) receptor 3, family member C|5-hydroxytryptamine receptor 3 subunit C|5-hydroxytryptamine receptor 3C|serotonin receptor 3C
|
| Swissprots |
Q8WXA8 A2RRR5
|
| Accessions |
EAW78305 Q8WXA8 AF459285 AAL66182 BC131799 AAI31800 NM_130770 NP_570126
|
| Function |
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:17392525}; Multi-pass membrane protein {ECO:0000269|PubMed:17392525}. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.
|
| Tissue Specificity |
Expressed in many tissues including adult brain, colon, intestine, lung, muscle and stomach as well as fetal colon and kidney. {ECO:0000269|PubMed:12801637}.
|
![Western Blot: HTR3C Overexpression Lysate (Adult Normal) [NBP2-05732] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for HTR3C.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/14956_HTR3C%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-05732-img0001.jpg)