| Gene Symbol | Dnaja1 |
|---|---|
| Entrez Gene | 15502 |
| Alt Symbol | Hsj2, Nedd7 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | DnaJ (Hsp40) homolog, subfamily A, member 1 |
| Other Description | HSJ-2|dnaJ homolog subfamily A member 1|dnaJ protein homolog 2|heat shock 40 kDa protein 4|heat shock protein J2|heat shock protein, Dnaj-like 2|neural precursor cell expressed, developmentally down-regulated gene 7 |
| Swissprots | P63037 P54102 |
| Accessions | BAD82815 EDL05430 EDL05431 EDL05432 EDL05433 EDL05434 P63037 AF055664 AAC78597 AI852330 AK049963 AK083046 BAC38744 AK145963 BAE26788 AK147604 AK163758 AK167139 BAE39284 AK167212 BAE39339 BB574002 BC057876 AAH57876 BC060653 BC158024 AAI58025 BY245852 CK617936 CN669546 D10917 NM_001164671 NP_001158143 NM_001164672 NP_001158144 NM_008298 NP_032324 |
| Function | Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity). Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. {ECO:0000250, ECO:0000269|PubMed:14752510}. |
| Subcellular Location | Membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Cytoplasm {ECO:0000250}. Microsome {ECO:0000250}. Mitochondrion {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Note=Primarily cytoplasmic and associated with microsomes. A minor proportion is associated with nuclei and mitochondria (By similarity). {ECO:0000250}. |
| Top Pathways | Protein processing in endoplasmic reticulum |