GBA2

Gene Symbol GBA2
Entrez Gene 57704
Alt Symbol AD035, NLGase, SPG46
Species Human
Gene Type protein-coding
Description glucosidase, beta (bile acid) 2
Other Description beta-glucocerebrosidase 2|glucosylceramidase 2|non-lysosomal glucosylceramidase
Swissprots D3DRP2 Q96LY1 Q96A51 Q9H2L8 Q96SJ2 Q5TCV6 Q9HCG7
Accessions EAW58345 EAW58346 EAW58347 EAW58348 EAW58349 Q9HCG7 AB046825 BAB13431 AF258662 AAG44660 AJ309567 CAC83792 AK027884 BAB55430 AK057610 AK295967 BAH12232 AK297435 BAG59862 AL834306 CAD38976 BC011363 AAH11363 XM_005251526 XP_005251583 XM_006716809 XP_006716872 XM_011517969 XP_011516271 XM_011517970 XP_011516272 XM_011517971 XP_011516273 XM_011517972 XP_011516274 XM_011517973 XP_011516275 XM_011517974 XP_011516276 XM_011517975 XP_011516277 XM_011517976 XP_011516278 XM_011517977 XP_011516279 XM_011517978 XP_011516280 XM_011517979 XP_011516281 NM_020944 NP_065995
Function Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide (GlcCer) to free glucose and ceramide. Involved in sphingomyelin generation and prevention of glycolipid accumulation. May also catalyze the hydrolysis of bile acid 3-O-glucosides, however, the relevance of such activity is unclear in vivo. Plays a role in central nevous system development. Required for proper formation of motor neuron axons. {ECO:0000269|PubMed:17105727, ECO:0000269|PubMed:23332916}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Not localized to lipid rafts. {ECO:0000269|PubMed:17105727}.
Tissue Specificity Widely expressed. Highly expressed in brain, heart, skeletal muscle, kidney and placenta and expressed at lower level in liver. {ECO:0000269|PubMed:11489889}.
Top Pathways Sphingolipid metabolism, Other glycan degradation

β-glucosidase 2 (G-15) - sc-160379 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

β-glucosidase 2 (P-17) - sc-160381 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-GBA2 antibody - ab69366 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-GBA2 antibody (ab69366) at 1/500 dilutionLane 1 : GBA2 transfected 293T lysateLane 2 : Non-transfected 293T lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

Anti-GBA2 Antibody - LS-C308060 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

GBA2 Antibody - NBP1-89251 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: GBA2 Antibody [NBP1-89251] - Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm, cytosol & the Golgi apparatus.

GBA2 Antibody - H00057704-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: GBA2 Antibody [H00057704-B01P] - Analysis of GBA2 expression in transfected 293T cell line by GBA2 polyclonal antibody. Lane1:GBA2 transfected lysate(101.97 KDa). Lane2:Non-transfected lysate.

GBA2 Polyclonal Antibody - bs-13297R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

GBA2 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-13297R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

GBA2 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-13297R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

GBA2 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-13297R-A555 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

GBA2 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-13297R-A647 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

GBA2 Polyclonal Antibody, Cy3 Conjugated - bs-13297R-Cy3 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

GBA2 Polyclonal Antibody, Cy5 Conjugated - bs-13297R-Cy5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

GBA2 Polyclonal Antibody, Cy5.5 Conjugated - bs-13297R-Cy5.5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

GBA2 Polyclonal Antibody, Cy7 Conjugated - bs-13297R-Cy7 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

GBA2 Polyclonal Antibody, FITC Conjugated - bs-13297R-FITC from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-GBA2 Polyclonal Antibody, PE Conjugated - bs-13297R-PE from Bioss

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

GBA2 Polyclonal Antibody, Biotin Conjugated - bs-13297R-Biotin from Bioss

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

GBA2 Polyclonal Antibody, HRP Conjugated - bs-13297R-HRP from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-GBA2 antibody produced in rabbit - HPA024026 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-GBA2: <B>Cat. No. HPA024026</B>: Immunohistochemical staining of human duodenum shows strong cytoplasmic positivity in glandular cells.

Anti-GBA2 antibody produced in mouse - SAB1407808 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-GBA2: <B>Cat. No. SAB1407808</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~102 kDa using GBA2 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

GBA2 Antibody (OABF00637) - OABF00637 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

GBA2 antibody - 70R-17433 from Fitzgerald

Prices $375.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Beta-glucosidase 2 antibody - 17164-1-AP from Acris Antibodies

Prices $270.00
Sizes 150 µl
Host Rabbit
Clonality Polyclonal
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