| Gene Symbol |
ZNF93
|
| Entrez Gene |
81931
|
| Alt Symbol |
HPF34, HTF34, TF34, ZNF505
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
zinc finger protein 93
|
| Other Description |
zinc finger protein 505|zinc finger protein HTF34
|
| Swissprots |
P35789 Q9H9X5 Q8N8Q4 Q9Y2N8 A6NMY2 B9EGT2
|
| Accessions |
AAA83548 AAD22981 EAW84865 EAW84866 EAW84867 P35789 AK022550 BAB14093 AK096342 BAC04764 AK295921 BAG58708 BC020837 BC038096 BC039001 BC058821 BC070372 AAH70372 BC107581 AAI07582 BC136718 AAI36719 BC136719 AAI36720 BG257405 BG289439 BG542138 BM842045 BU165449 XM_011528339 XP_011526641 NM_001004126 NM_031218 NP_112495
|
| Function |
Transcription factor specifically required to repress long interspersed nuclear element 1 (L1) retrotransposons: recognizes and binds L1 sequences and repress their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305). Not able to repress expression of all subtypes of L1 elements. Binds to the 5' end of L1PA4, L1PA5 and L1PA6 subtypes, and some L1PA3 subtypes. Does not bind to L1PA7 or older subtypes nor at the most recently evolved L1PA2 and L1Hs. 50% of L1PA3 elements have lost the ZNF93-binding site, explaining why ZNF93 is not able to repress their expression (PubMed:25274305). {ECO:0000269|PubMed:25274305}.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|